{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:38:26Z","timestamp":1790469506432,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","award":["19\u2010L\u20100170"],"award-info":[{"award-number":["19\u2010L\u20100170"]}],"id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008218","name":"Gangstedfonden","doi-asserted-by":"publisher","award":["A38495"],"award-info":[{"award-number":["A38495"]}],"id":[{"id":"10.13039\/501100008218","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have investigated long\u2010term survival in patients with primary immune thrombocytopenia (pITP). Further, changes in prognosis over the past decades and prognosis of secondary immune thrombocytopenia (sITP) are largely unstudied. Our objectives were to study comorbidity\u2010adjusted prognostic changes and causes of death in chronic pITP and sITP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Methods<\/jats:title><jats:p>Using nationwide Danish health registries 1980\u20132016, we identified 1762 patients with chronic pITP (median age 58 (IQR, 37\u201373) years) and 128 with chronic sITP (median age 59 (IQR, 40\u201373) years). Patients were age\u2010sex\u2010matched to 74,781 general population comparators.<\/jats:p><jats:p>Comorbidity was assessed using Charlson Comorbidity Index (CCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall median survival was reduced by 5.1\u2009years (95% CI, 0.7\u20139.4) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) for pITP and 11.1\u2009years (95% CI, 5.8\u201316.4) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) for sITP. 5\u2010year survival increased from 69% (95% CI, 59\u201378) in 1980\u201389 to 80% (95% CI, 75\u201383) in 2010\u201316 for pITP, and decreased from 100% (95% CI, 89\u201398) to 64% (95% CI, 87\u201391) for sITP. However, numbers were small for sITP. 5\u2010year survival for pITP with high CCI was 41% (95% CI, 32\u201349), and 85% (95% CI, 83\u201387) for low CCI.<\/jats:p><jats:p>Bleeding, infection and hematological cancer were relatively frequent causes of death with adjusted subhazard ratios of 3.25 (95% CI, 2.33\u20134.52), 1.53 (95% CI, 1.08\u20132.16) and 2.16 (95% CI, 1.12\u20134.16) in pITP respectively, and 10.52 (95% CI, 1.43\u201377.36) for hematological cancer in sITP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term survival is reduced in chronic ITP but seems to be improving. Comorbidity and sITP are associated with a poor prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17212","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T08:16:18Z","timestamp":1672906578000},"page":"415-426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Survival in adult patients with chronic primary and secondary immune thrombocytopenia: A population\u2010based study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1098-8134","authenticated-orcid":false,"given":"Nikolaj","family":"Mannering","sequence":"first","affiliation":[{"name":"Department of Hematology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4478-1297","authenticated-orcid":false,"given":"Dennis Lund","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Hematology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-5679","authenticated-orcid":false,"given":"Anton","family":"Potteg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8905-0220","authenticated-orcid":false,"given":"Henrik","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"Department of Hematology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-129155"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-312819"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-013-1370-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2703-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2008.12.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2008.12.006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-162503"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-578336"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24310"},{"key":"e_1_2_10_11_1","unstructured":"Sest\u00f8lHG Sine MunchTrangb\u00e6k James BBussel HenrikFrederiksen.Health related quality of life in adult primary immune thrombocytopenia2018. 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