{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:44:24Z","timestamp":1787921064594,"version":"build-2784847793"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sickle cell trait (SCT) testing of red blood cell (RBC) units is sometimes performed to identify and divert units containing hemoglobin S (HbS). Recipients strategically guarded against this exposure include fetuses, neonates, and children with sickle cell disease (SCD). The clinical necessity of this practice is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>A one\u2010year audit (2018) was performed at a pediatric tertiary care hospital that tests for SCT in RBC units prescribed to children with SCD and neonates. The impact of incorporating varying numbers of SCT RBC units in a single\u2010unit top\u2010up, partial\u2010manual red cell exchange, and automated erythrocytapheresis was modeled in four typical\u2010parameter age scenarios (2, 5, 10, and 18\u2009years) sharing a high baseline HbS. Additionally, a survey assessing SCT testing practices was administered to Canadian pediatric hospital transfusion laboratories serving hemoglobinopathy programs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2268 donor RBC units tested, one was positive for SCT (0.04% [95% CI: 0.01%\u20130.24%]), at a cost of $19,384.56 CAD. The impact of SCT unit incorporation on lost HbS reduction was modest (\u03941%\u20133% [automated erythrocytapheresis] and \u03944%\u201315% [top\u2010up\/partial manual exchange]). The survey (with all 13 sites responding) showed variable SCT testing practice; four (31%) do not test, four (31%) test for children with SCD, and six (46%) test for neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RBC SCT testing may be more costly than beneficial or necessary in children with SCD. As of 2019, our transfusion service has ceased SCT testing for this population. Further research in the fetal\/neonatal populations is needed to overturn this entrenched practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17223","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T12:55:26Z","timestamp":1671108926000},"page":"507-514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reconsidering sickle cell trait testing of red blood cell units allocated to children with sickle cell disease"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4292-3105","authenticated-orcid":false,"given":"Omar I.","family":"Hajjaj","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine &amp; Molecular Diagnostics Sunnybrook Health Sciences Centre  Toronto Ontario Canada"},{"name":"University of Toronto Quality in Utilization Education &amp; Safety in Transfusion (QUEST) Research Program  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5297-6406","authenticated-orcid":false,"given":"Christine","family":"Cserti\u2010Gazdewich","sequence":"additional","affiliation":[{"name":"University of Toronto Quality in Utilization Education &amp; Safety in Transfusion (QUEST) Research Program  Toronto Ontario Canada"},{"name":"Department of Clinical Pathology University Health Network  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letka","family":"Dumevska","sequence":"additional","affiliation":[{"name":"Department of Paediatric Laboratory Medicine Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirette","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Department of Paediatric Laboratory Medicine Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Department of Paediatric Laboratory Medicine Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Canadian Blood Services Donor and Clinical Services  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3633-0728","authenticated-orcid":false,"given":"Lani","family":"Lieberman","sequence":"additional","affiliation":[{"name":"University of Toronto Quality in Utilization Education &amp; Safety in Transfusion (QUEST) Research Program  Toronto Ontario Canada"},{"name":"Department of Clinical Pathology University Health Network  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Canadian Obstetrical Pediatric Transfusion Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807023390102"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-009506"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb08351.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14383"},{"key":"e_1_2_9_6_1","unstructured":"American Red Cross.Blood Donation Eligibility Criteria.2022; Available at:https:\/\/www.redcrossblood.org\/donate-blood\/how-to-donate\/eligibility-requirements.html. 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