{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:18:46Z","timestamp":1790806726475,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1K23HL15182"],"award-info":[{"award-number":["1K23HL15182"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prior to laboratory\u2010based blood donor screening for <jats:italic>Babesia<\/jats:italic>, transfusion\u2010transmitted babesiosis (TTB) was a leading infectious risk to the blood supply in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>A 30\u2010year\u2010old man with sickle cell disease (SCD) who had been on a chronic automated red cell exchange (RCE) regimen since childhood, presented approximately 2\u2009months after an RCE, with fever, neck pain, and photophobia. Meningitis was excluded, and he was discharged. He presented again 2\u2009days later with persistent fever, chills, headache, fatigue, and loss of appetite.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On examination, the patient was febrile but hemodynamically stable. Intra\u2010erythrocytic inclusions were identified on a peripheral blood smear (&lt;0.5%). <jats:italic>B.\u00a0microti<\/jats:italic> IgM and IgG titers were\u2009&gt;1:320 (Reference &lt;1:20) &gt;1:1024 (Reference &lt;1:64), respectively. <jats:italic>B.\u00a0microti<\/jats:italic> was confirmed by nucleic acid testing. The patient lived in a <jats:italic>Babesia<\/jats:italic> endemic state but had no risk factors for tick\u2010borne acquisition. Of the 65\u2009units he received in the preceding 6\u2009months, 58 had been screened for <jats:italic>Babesia<\/jats:italic>. One of the donors of the 7 untested units was <jats:italic>B. microti<\/jats:italic> seropositive (titer 1:128; Reference 1: 64). The donor was asymptomatic and resided in a state in which <jats:italic>Babesia<\/jats:italic> screening was not required. He reported traveling in the year before his donation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although rare, TTB is still possible despite regional screening, underscoring the need for provider vigilance and education, especially in non\u2010endemic areas. Patients with SCD are particularly vulnerable given their high frequency of transfusion and complex needs requiring blood procurement from states where <jats:italic>Babesia<\/jats:italic> screening is not mandatory.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17244","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T18:32:47Z","timestamp":1673634767000},"page":"652-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Transfusion\u2010transmitted babesiosis in a patient with sickle cell disease undergoing chronic red cell exchange"],"prefix":"10.1111","volume":"63","author":[{"given":"Victoria","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Mercure\u2010Corriveau","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Gourneau","sequence":"additional","affiliation":[{"name":"American Red Cross  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-3766","authenticated-orcid":false,"given":"Aaron A. R.","family":"Tobian","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Hematology Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Lauriello","sequence":"additional","affiliation":[{"name":"Department of Hematology Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lanzkron","sequence":"additional","affiliation":[{"name":"Department of Hematology Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-2800","authenticated-orcid":false,"given":"Elizabeth P.","family":"Crowe","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8181-9517","authenticated-orcid":false,"given":"Evan M.","family":"Bloch","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1202018"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2802.210213"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00362"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10091176"},{"key":"e_1_2_7_6_1","volume-title":"Recommendations for Reducing the Risk of Transfusion\u2010Transmitted Babesiosis","author":"FDA","year":"2019"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16718"},{"key":"e_1_2_7_8_1","unstructured":"CDC.Parasites\u2010Babesiosis National Surveillance [monograph on the internet].2018. Available from:https:\/\/www.cdc.gov\/parasites\/babesiosis\/surveillance.html"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10111435"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26734"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2015.06.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12086"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600897"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens8030102"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17244","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.17244","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T10:55:25Z","timestamp":1692528925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.17244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,13]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/trf.17244"],"URL":"https:\/\/doi.org\/10.1111\/trf.17244","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,13]]},"assertion":[{"value":"2022-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}