{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T20:14:46Z","timestamp":1775506486314,"version":"3.50.1"},"reference-count":6,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The clinical significance of serologic reactivity of unidentified specificity (SRUS) in pregnancy is not clear based on available literature. The aim of this study is to determine if SRUS is associated with hemolytic disease of the fetus and newborn (HDFN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Retrospective data were collected from eight institutions over an 11\u2010year study period (2010\u20132020), when available (5\/8 sites). The outcome of the pregnancies with SRUS\u2014no, mild, moderate, or severe HDFN\u2014was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SRUS was demonstrated in 589 pregnancies. After excluding those with incomplete data, a total of 284 pregnancies were included in the primary HDFN outcome analysis. SRUS was detected in 124 (44%) pregnancies in isolation, and none were affected by HDFN. Of 41 pregnancies with SRUS and ABO incompatibility, 37 (90%) were unaffected, and 4 (10%) were associated with mild HDFN. Of 98 pregnancies with SRUS and concurrent identifiable antibody\u00a0reactivity(s), 80 (81%) were unaffected, and 19 (19%) were associated with mild to severe HDFN. There was 1 case of mild HDFN and 1 case of severe HDFN in the 21 pregnancies with SRUS, ABO incompatibility, and concurrent identifiable antibody\u00a0reactivity(s), and 19 (90%) were unaffected by HDFN. Among all patients with repeat testing, newly identified alloantibodies or other antibodies were identified in 63 of 212 (30%) patients. Although most were not clinically significant, on occasion SRUS preceded clinically significant antibody(s) associated with HDFN (3%, 5\/188).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The antenatal serologic finding of SRUS in isolation is not associated with HDFN but may precede clinically significant antibodies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17276","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T10:18:54Z","timestamp":1677147534000},"page":"817-825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Serologic reactivity of unidentified specificity in antenatal testing and hemolytic disease of the fetus and newborn: The <scp>BEST<\/scp> collaborative study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2292-3167","authenticated-orcid":false,"given":"Wen","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1814-9319","authenticated-orcid":false,"given":"Alyssa","family":"Ziman","sequence":"additional","affiliation":[{"name":"Wing\u2010Kwai and Alice Lee\u2010Tsing Chung Transfusion Service, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine University of California Los Angeles  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6404-1931","authenticated-orcid":false,"given":"Matthew T. S.","family":"Yan","sequence":"additional","affiliation":[{"name":"Canadian Blood Services  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5048-5021","authenticated-orcid":false,"given":"Allison","family":"Waters","sequence":"additional","affiliation":[{"name":"Irish Blood Transfusion Service  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3232-2090","authenticated-orcid":false,"given":"Mrigender Singh","family":"Virk","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Service, Department of Pathology Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7107-2595","authenticated-orcid":false,"given":"Andrew W.","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edel","family":"Scally","sequence":"additional","affiliation":[{"name":"Irish Blood Transfusion Service  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay S.","family":"Raval","sequence":"additional","affiliation":[{"name":"Transfusion Medicine and Therapeutic Pathology, Department of Pathology University of New Mexico  Albuquerque New Mexico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3614-2353","authenticated-orcid":false,"given":"Suchi","family":"Pandey","sequence":"additional","affiliation":[{"name":"Stanford Blood Center  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5183-6471","authenticated-orcid":false,"given":"Monica B.","family":"Pagano","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Transfusion Medicine Division University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3764-1787","authenticated-orcid":false,"given":"Hua","family":"Shan","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Service, Department of Pathology Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmel","family":"Moore","sequence":"additional","affiliation":[{"name":"National Maternity Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine BC Women's and Children's Hospital  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orla","family":"Cormack","sequence":"additional","affiliation":[{"name":"National Maternity Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"National Maternity Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Duncan","sequence":"additional","affiliation":[{"name":"Vancouver Island Health Authority  Courtenay British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Corean","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Service, Department of Pathology Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwen","family":"Clarke","sequence":"additional","affiliation":[{"name":"Canadian Blood Services  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6740-2758","authenticated-orcid":false,"given":"Mark","family":"Yazer","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200608000-00044"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12091"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.3109\/14767058.2015.1107540","article-title":"Non\u2010specific red cell reactivity in an obstetric population","volume":"29","author":"Van Winden KR","year":"2016","journal-title":"J Matern Fetal Neonatal 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