{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:27:14Z","timestamp":1754108834324,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T00:00:00Z","timestamp":1677283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL126130"],"award-info":[{"award-number":["R01HL126130"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Growing evidence suggests multiple pathophysiological mechanisms linking red blood cells (RBC) transfusions to thrombosis. This study examined blood donor, component, and recipient factors which may be associated with thromboembolic outcomes following RBC transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We utilized the Recipient Epidemiology Donor Evaluation Study\u2010III (REDS\u2010III) database on patients transfused in 12 hospitals between 2013\u20132016. Stratified Cox proportional hazards regression models with time\u2010dependent exposures were used to examine associations of donor and component modification characteristics on venous thromboembolism (VTE) in patients transfused RBC units.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>59,603 patients were transfused 229,500 RBC units during 79,298 hospitalizations with post\u2010transfusion VTE occurring in 1869 (2.4%) of patients. In adjusted regression analyses, a per RBC\u2010unit risk of VTE was present for gamma irradiation (HR\u00a0=\u00a01.03; 95% CI: 1.02\u20131.03), female donor sex (HR\u00a0=\u00a01.01; 95% CI: 1.00\u20131.01), storage duration greater than 5\u2009weeks (HR\u00a0=\u00a01.01; 95% CI: 1.01\u20131.02), AS\u20101 storage solution (HR\u00a0=\u00a01.01; 95% CI: 1.00\u20131.01), and apheresis\u2010derived collections (HR\u00a0=\u00a01.01; 95% CI: 1.01\u20131.02). Among recipient factors, male sex (HR\u00a0=\u00a01.03; 95% CI: 1.02\u20131.04), pre\u2010transfusion hemoglobin level (HR\u00a0=\u00a00.94; 95% CI: 0.94\u20130.94), body mass index strata (HR\u00a0=\u00a01.11; 95% CI: 1.08\u20131.14), and principal diagnoses including malignancy (HR\u00a0=\u00a01.13; 95% CI: 1.10\u20131.16), cardiac arrest (HR\u00a0=\u00a01.38; 95% CI:1.07\u20131.77) and hip fracture (HR\u00a0=\u00a01.59; 95% CI:1.53\u20131.66) were associated with VTE in adjusted analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>We identified several donor, component, and recipient\u2010specific factors associated with VTE in transfused hospitalized adult patients. In adjusted models, the dose\u2010dependent associations of donor and component\u2010specific factors with VTE were modest and unlikely to be clinically significant in the majority of transfused patients. Additional mechanistic and clinical studies linking blood donor and component factors with thrombotic outcomes are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17292","type":"journal-article","created":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T08:24:42Z","timestamp":1677313482000},"page":"925-932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Blood donor, component, and <scp>recipient\u2010specific<\/scp> factors associated with venous thromboembolism in transfused hospitalized adult patients: Data from the recipient epidemiology and donor evaluation <scp>Study\u2010III<\/scp> (<scp>REDS\u2010III<\/scp>)"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9653-9905","authenticated-orcid":false,"given":"Ruchika","family":"Goel","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Pediatrics Simmons Cancer Institute at SIU School of Medicine  Springfield Illinois USA"},{"name":"Division of Transfusion Medicine, Department of Pathology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen","family":"Plimier","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Lee","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-3766","authenticated-orcid":false,"given":"Aaron A. R.","family":"Tobian","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine, Department of Pathology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2543-991X","authenticated-orcid":false,"given":"Cassandra D.","family":"Josephson","sequence":"additional","affiliation":[{"name":"Department of Oncology and Cancer and Blood Disorders Institute Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Johns Hopkins All Children's Hospital  St. Petersburg Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2367-9509","authenticated-orcid":false,"given":"Eldad A.","family":"Hod","sequence":"additional","affiliation":[{"name":"Department of Pathology Columbia University Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nareg H.","family":"Roubinian","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research  Oakland California USA"},{"name":"Vitalant Research Institute  San Francisco California USA"},{"name":"UCSF Department of Laboratory Medicine  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.83"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1311-6"},{"key":"e_1_2_8_4_1","unstructured":"CDC.Centers for Disease Control and Prevention 2017.https:\/\/www.cdc.gov\/ncbddd\/dvt\/ha-vte-data.html."},{"key":"e_1_2_8_5_1","unstructured":"The sugeon general's Call to Action to Prevent Deep Venous thrombosis and Pulmonary 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