{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:19:53Z","timestamp":1788347993616,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100019260","name":"Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria","doi-asserted-by":"publisher","award":["441768\/2017\u20102"],"award-info":[{"award-number":["441768\/2017\u20102"]}],"id":[{"id":"10.13039\/501100019260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Asymptomatic visceral leishmaniasis (VL) infection is a risk for transfusion safety. Leukoreduction has been an alternative for the prevention of some blood\u2010borne diseases, including VL. This study aimed to evaluate the role of leukoreduction of cellular blood components as a control measure for transfusional VL transmission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Research Design and Methods<\/jats:title><jats:p>A total of 161 polytransfused patients with non\u2010leukoreduced blood components (HNL), 95 polytransfused with leukoreduced blood components (LH), and 202 non\u2010transfused (NT) from endemic regions for VL and with a similar epidemiological profile. The detection of antibodies against VL was performed by ELISA and the presence of the parasite was investigated by real\u2010time PCR. Statistical significance was defined as <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When comparing three groups, ELISA results were statistically significant (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0065). The residual analysis of ELISA showed statistically significant for the HNL group compared to the general group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002; OR: 5.6; CI: 1.7\u201325.8), demonstrating that individuals who received non\u2010leukoreduced transfusions are five times more likely to acquire <jats:italic>Leishmania infantum<\/jats:italic> infection than the general.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Higher prevalence in the group with HNL and low prevalence in those who received LH, similar to NT patients, highlight the risk of transfusional VL transmission and reinforce the role of leukoreduction in its prevention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17308","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T13:25:38Z","timestamp":1679059538000},"page":"1044-1049","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Leukoreduction as a control measure in transfusion transmission of visceral leishmaniasis"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2891-443X","authenticated-orcid":false,"given":"Loren Queli","family":"Pereira","sequence":"first","affiliation":[{"name":"Laboratory of Hematological Research Tri\u00e2ngulo Mineiro Federal University  Uberaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Cristina Sato Vaz","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Laboratory of Hematological Research Tri\u00e2ngulo Mineiro Federal University  Uberaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Maria","family":"Ferreira\u2010Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Hematological Research Tri\u00e2ngulo Mineiro Federal University  Uberaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca V\u00e2nia Barreto Aguiar Ferreira","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Health of Government of the State of Cear\u00e1 Hemoce \u2010 Center for Hematology and Hemotherapy of the State of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Palis","family":"Santana","sequence":"additional","affiliation":[{"name":"Government of Piau\u00ed Hemopi \u2010 Hematology and Hemotherapy Center of the State of Piau\u00ed  Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Roberto","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Hemominas Foundation Regional Blood Center of Montes Claros (Minas Gerais)  Montes Claros Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"de Ara\u00fajo Pereira","sequence":"additional","affiliation":[{"name":"Department of Nursing in Education and Community Health Federal University of Tri\u00e2ngulo Mineiro  Uberaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"G\u00f3mez\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology Tri\u00e2ngulo Mineiro Federal University  Uberaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virmondes Rodrigues","family":"Junior","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology Tri\u00e2ngulo Mineiro Federal University  Uberaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Bernadelli","family":"De Vito","sequence":"additional","affiliation":[{"name":"Laboratory of Hematological Research Tri\u00e2ngulo Mineiro Federal University  Uberaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helio","family":"Moraes\u2010Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Hematological Research Tri\u00e2ngulo Mineiro Federal University  Uberaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035671"},{"key":"e_1_2_9_3_1","unstructured":"WHO.World Health Organization 2020. 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