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Adult studies suggest administering high\u2010titer CCP early in the disease course of patients who are expected to be antibody\u2010negative; however, pediatric experience is limited. We created a multi\u2010institutional registry to characterize pediatric patients (&lt;18\u2009years) who received CCP and to assess the safety of this intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A REDCap survey was distributed. The registry collected de\u2010identified data including demographic information (age, gender, and underlying conditions), COVID\u201019 disease features and concurrent treatments, CCP transfusion and safety events, and therapy response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010five children received CCP: 90 inpatients and 5 outpatients, with a median age of 10.2\u2009years (range 0\u201317.9). They were predominantly Latino\/Hispanic and White. The most frequent underlying medical conditions were chronic respiratory disease, immunosuppression, obesity, and genetic syndromes. CCP was primarily given as a treatment (95%) rather than prophylaxis (5%). Median total plasma dose administered and transfusion rates were 5.0\u2009ml\/kg and 2.6\u2009ml\/kg\/h, respectively. The transfusions were well\u2010tolerated, with 3 in 115 transfusions reporting mild reactions. No serious adverse events were reported. Severity scores decreased significantly 7\u2009days after CCP transfusion or at discharge. Eighty\u2010five patients (94.4%) survived to hospital discharge. All five outpatients survived to 60\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CCP was found to be safe and well\u2010tolerated in children. CCP was frequently given concurrently with other COVID\u201019\u2010directed treatments with improvement in clinical severity scores \u22657\u2009days after CCP, but efficacy could not be evaluated in this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17318","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T20:07:28Z","timestamp":1679774848000},"page":"918-924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multi\u2010institutional experience with COVID\u201019 convalescent plasma in children"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1281-0644","authenticated-orcid":false,"given":"Cyril","family":"Jacquot","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Children's National Hospital  District of Columbia Washington USA"},{"name":"Departments of Pathology and Pediatrics George Washington University School of Medicine and Health Sciences  Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oren","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Noland","sequence":"additional","affiliation":[{"name":"Children's Health Dallas\/UTSW  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R.","family":"Donowitz","sequence":"additional","affiliation":[{"name":"Children's Hospital of Richmond at Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8447-7663","authenticated-orcid":false,"given":"Emily","family":"Levy","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester, Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Willis","sequence":"additional","affiliation":[{"name":"UNC Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casey","family":"Rimland","sequence":"additional","affiliation":[{"name":"UNC Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Loi","sequence":"additional","affiliation":[{"name":"Children's Hospital Colorado  Aurora Colorado USA"},{"name":"University of Colorado\u2010Anschutz School of Medicine Dept. of Pathology  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Arrieta","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Children's Hospital of Orange County  Orange California USA"},{"name":"Department of Pediatrics University of California at Irvine  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Annen","sequence":"additional","affiliation":[{"name":"Children's Hospital Colorado  Aurora Colorado USA"},{"name":"University of Colorado\u2010Anschutz School of Medicine Dept. of Pathology  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelle","family":"Drapeau","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester, Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Osborne","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Children's Hospital of Orange County  Orange California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica I.","family":"Ardura","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases &amp; Host Defense Program Nationwide Children's Hospital, The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9048-5624","authenticated-orcid":false,"given":"Satyam","family":"Arora","sequence":"additional","affiliation":[{"name":"Postgraduate Institute of Child Health  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Zivick","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1089-5787","authenticated-orcid":false,"given":"Meghan","family":"Delaney","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Children's National Hospital  District of Columbia Washington USA"},{"name":"Departments of Pathology and Pediatrics George Washington University School of Medicine and Health Sciences  Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/M22-1079"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2119657"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac724"},{"key":"e_1_2_9_5_1","first-page":"7","article-title":"Pharmacokinetics of high\u2010titer anti\u2010SARS\u2010CoV\u20102 human convalescent plasma in high\u2010risk children. 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