{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:09:30Z","timestamp":1787062170378,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous mixed findings on the associations between whole blood (WB) donation and risk of cardiovascular diseases (CVD) may in part reflect inadequate adjustment for the \u201chealthy donor effect\u201d (HDE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used the Sax Institute's 45 and Up Study linked with blood donation history and other health\u2010related databases to examine the association between regular, high\u2010frequency WB donation and the risk of CVD. To mitigate the impact of HDE, we used a \u201c5\u2010years qualification period,\u201d in which donors must donate at least 1 WB donation in the 1st and 5th year of \u201cqualification period.\u201d We then compared the risk of CVD in the years following the \u201cqualification period\u201d between the regular high\u2010frequency WB donors (\u22652 WB donation in each qualification year) and others using Cox proportional\u2010hazards models. Analyses were adjusted for potential confounders, such as sociodemographic, lifestyle, and health\u2010related variables, and results are reported separately for male and female donors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2736 male and 2917 female donors were included in the analyses. The median years of follow\u2010up per donor was 5.84\u2009years (Q1\u2010Q3, 5.47\u20136.23). The rate of CVD hospitalization was 11.20 and 4.50 per 1000 person\u2010years for males and females, respectively. In fully adjusted models, the risk (hazard ratio) of CVD in regular high\u2010frequency donors compared to other donors was 0.93 (95% Confidence Interval (CI), 0.68\u20131.29) for males and 0.79 (95% CI, 0.49\u20131.28) for females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We did not observe a statistically significant reduction of CVD risk in regular, high\u2010frequency WB donors when adjusted for potential confounders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.17358","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T05:20:51Z","timestamp":1681449651000},"page":"1012-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Regular high\u2010frequency whole blood donation and risk of cardiovascular disease in middle\u2010aged and older blood donors in Australia"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1561-4171","authenticated-orcid":false,"given":"Surendra","family":"Karki","sequence":"first","affiliation":[{"name":"Research and Development Australian Red Cross Lifeblood  Sydney New South Wales Australia"},{"name":"School of Population Health UNSW Australia  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy J. L.","family":"Bell","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hayen","sequence":"additional","affiliation":[{"name":"School of Public Health University of Technology  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bette","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Population Health UNSW Australia  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Cust","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"The Daffodil Centre The University of Sydney, a Joint Venture with Cancer Council NSW  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0417-3411","authenticated-orcid":false,"given":"John K.","family":"Olynyk","sequence":"additional","affiliation":[{"name":"School of Health and Medical Sciences Edith Cowan University  Bull Creek Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O.","family":"Irving","sequence":"additional","affiliation":[{"name":"Research and Development Australian Red Cross Lifeblood  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,14]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"143","article-title":"Adverse reactions during voluntary donation of blood and\/or blood components. A statistical\u2010epidemiological study","volume":"5","author":"Crocco A","year":"2007","journal-title":"Blood Transfus"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92463-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70174-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890310016342"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.119"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60484-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12032"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753944714553226"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659113505637"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.083"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20040278"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.78.2.188"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009669"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.1.52"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12081"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.03055.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00186.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2018-314138"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2022.04.004"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym184"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyac104"},{"key":"e_1_2_9_23_1","unstructured":"Center for Health Record Linkage.Data dictionaries\u2014NSW Admitted Patient Data Collection (APDC).http:\/\/www.cherel.org.au\/data-dictionaries#section1. Accessed [January 2020]"},{"key":"e_1_2_9_24_1","unstructured":"Centre for Health Record Linkage.Data dictionaries\u2010 NSW Birth Registration Data Collection.http:\/\/www.cherel.org.au\/data-dictionaries. Accessed [January 16 2020]"},{"key":"e_1_2_9_25_1","unstructured":"Centre for Health Record Linkage (CHeReL).Quality assurance.http:\/\/www.cherel.org.au\/media\/24160\/qa_report_2012.pdf. Accessed [June 05 2018]"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.192"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T16:21:33Z","timestamp":1692634893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.17358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,14]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/trf.17358"],"URL":"https:\/\/doi.org\/10.1111\/trf.17358","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,14]]},"assertion":[{"value":"2022-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}