{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:18:42Z","timestamp":1790806722610,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000014","name":"Canadian Blood Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In Canada the time deferral for gay, bisexual, and other men who have sex with men (gbMSM) was progressively shortened (lifetime, 5\u2009years, 1\u2009year, 3\u2009months). Here we describe trends in syphilis rates (a potential sexual risk marker) and risk behaviors from blood donors in the past 12\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Syphilis positivity in 10,288,322 whole blood donations (January 1, 2010\u2013September 10, 2022) and gbMSM deferral time periods, donation status, age, and sex were analyzed with logistic regression. Overall, 26.9% syphilis positive and 42.2% controls (matched 1:4) participated in risk factor interviews analyzed by logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Syphilis rates were higher in first\u2010time donors (OR 27.0, 95% CI 22.1\u201333.0), in males (OR 2.3, 1.9\u20132.8) and with the 3\u2010month deferral (OR 3.4, 2.6\u20134.3) during which the increase was greater for first\u2010time males (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) but similar for male and female repeat donors (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05). Among first\u2010time donors, histories of intravenous drug use (OR 11.7, 2.0\u201369.5), male\u2010to\u2010male sex 7.8 (2.0\u201330.2) and birth in a high prevalence country (OR 7.6, 4.4\u201313.0) predicted syphilis positivity; among repeat donors, history of male\u2010to\u2010male sex (OR 33.5, CI 3.5\u2013317.0). All but 1 gbMSM syphilis\u2010positive donors were noncompliant with the gbMSM deferral. About a quarter of first\u2010time interviewed case donors had history of syphilis; 44% were born in a high\u2010prevalence country.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rising syphilis rates in donors correlates with the general population epidemic. Recent infection rates rose similarly in males and females. GbMSM history may contribute to donor syphilis rates but shortening time deferrals appears unrelated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17393","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T13:28:02Z","timestamp":1683725282000},"page":"1195-1203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Monitoring syphilis serology in blood donors: Is there utility as a surrogate marker of early transfusion transmissible infection behavioral risk?"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5332-2789","authenticated-orcid":false,"given":"Sheila F.","family":"O'Brien","sequence":"first","affiliation":[{"name":"Canadian Blood Services  Ottawa Ontario Canada"},{"name":"School of Epidemiology &amp; Public Health University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2519-1109","authenticated-orcid":false,"given":"Steven J.","family":"Drews","sequence":"additional","affiliation":[{"name":"Canadian Blood Services  Edmonton Alberta Canada"},{"name":"Department of Laboratory Medicine &amp; Pathology University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010Long","family":"Yi","sequence":"additional","affiliation":[{"name":"Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Osmond","sequence":"additional","affiliation":[{"name":"Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Tran","sequence":"additional","affiliation":[{"name":"Microbiology, Public Health Ontario  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine &amp; Pathology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Microbiology ProvLab Alberta  Calgary Alberta Canada"},{"name":"Department of Pathology &amp; Laboratory Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9904-9952","authenticated-orcid":false,"given":"Mindy","family":"Goldman","sequence":"additional","affiliation":[{"name":"Canadian Blood Services  Ottawa Ontario Canada"},{"name":"Department of Pathology &amp; Laboratory Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17164"},{"key":"e_1_2_8_3_1","unstructured":"Canadian Blood Services. Accessed November 30 2022. Available from:https:\/\/www.blood.ca\/en\/blood\/am\u2010i\u2010eligible\u2010donate\u2010blood\/sexual\u2010behaviour\u2010based\u2010screening"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16696"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16655"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12741"},{"key":"e_1_2_8_7_1","first-page":"293","article-title":"Lessons learnt from syphilis\u2010infected blood donors: a timely reminder of missed opportunities","volume":"98","author":"Harvala H","year":"2022","journal-title":"Sex Transm Infect"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.14745\/ccdr.v48i23a01"},{"key":"e_1_2_8_9_1","unstructured":"Public Health Agency of Canada.Syphilis in Canada: Technical report on epidemiological trends determinants and interventions. Accessed January 16 2023. Available from:https:\/\/www.canada.ca\/en\/services\/health\/publications\/diseases-conditions\/syphilis-epidemiological-report.html"},{"key":"e_1_2_8_10_1","unstructured":"PanCanadian Action Plan (PHAC).Reducing the health impact of sexually transmitted and blood\u2010borne infections in Canada by 2030: a pan\u2010Canadian STBBI framework for action\u2014 Canada.ca."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001130"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.14745\/ccdr.v45i12a04"},{"key":"e_1_2_8_13_1","unstructured":"Canadian Blood Services.Surveillance Report 2021. Accessed January 16 2023. Available from:https:\/\/www.blood.ca\/sites\/default\/files\/Surveillance_Report_2021_EN.pdf"},{"key":"e_1_2_8_14_1","unstructured":"The Kirby Institute.Transfusion\u2010transmissible infections in Australia: surveillance report 2022. Accessed January 16 2023. Available from:https:\/\/kirby.unsw.edu.au\/report\u2010type\/australian\u2010blood\u2010donor\u2010surveillance\u2010reports"},{"key":"e_1_2_8_15_1","unstructured":"UK Health Security Agency and NHS Blood and Transplant.Safe supplies 2021: FAIRer donor selection. Accessed January 16 2023. Available from:https:\/\/nhsbtdbe.blob.core.windows.net\/umbraco\u2010assets\u2010corp\/27793\/annual\u2010review\u2010with\u2010a4\u2010infographics\u2010final\u2010accessible\u2010features\u2010v3.pdf"},{"key":"e_1_2_8_16_1","unstructured":"Safe Supplies: Data in Context.Annual review from the NHS blood and transplant\/public health england epidemiology unit.2019London. Accessed November 24 2022. Available from:https:\/\/hospital.blood.co.uk\/epidemiology-reports\/"},{"key":"e_1_2_8_17_1","unstructured":"Canadian Blood Services.Donor questionnaire for blood platelets and plasma. Accessed April 3 2023. Available from:https:\/\/www.blood.ca\/en\/blood\/donating-blood\/donor-questionnaire"},{"key":"e_1_2_8_18_1","unstructured":"Canadian Blood Services.ABCs of eligibility for donating blood platelets and plasma. Accessed January 16 2023. Available from:https:\/\/www.blood.ca\/en\/blood\/am-i-eligible-donate-blood\/abcs-eligibility"},{"key":"e_1_2_8_19_1","unstructured":"Canadian Blood Services.What you must know to donate blood. Accessed January 16 2023. Available fromhttps:\/\/www.blood.ca\/sites\/default\/files\/10552-BloodInfo_PamphletEN_Final.pdf"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2005\/597580"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15020409"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03403824"},{"key":"e_1_2_8_23_1","first-page":"178","article-title":"A deprivation index for health planning in Canada","volume":"29","author":"Pampalon R","year":"2009","journal-title":"Health Promot Chronis Dis Prev Can"},{"key":"e_1_2_8_24_1","unstructured":"World Health Organization Data on syphilis. Accessed December 9 2022. Available from: Data on syphilis (who.int)"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40471-018-0138-z"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/157.1.32"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16349"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16753"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2021-054981"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006890"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.14745\/ccdr.v48i23a03"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2007.00923.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15098"},{"key":"e_1_2_8_34_1","unstructured":"Public Health Agency of Canada.HIV in Canada surveillance report to December 31 2020. Accessed January 16 2023. Available from:https:\/\/www.canada.ca\/en\/public\u2010health\/services\/publications\/diseases\u2010conditions\/hiv\u2010canada\u2010surveillance\u2010report\u2010december\u201031\u20102020.html#f6a"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T06:52:24Z","timestamp":1714719144000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.17393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,9]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/trf.17393"],"URL":"https:\/\/doi.org\/10.1111\/trf.17393","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,9]]},"assertion":[{"value":"2023-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}