{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:52:20Z","timestamp":1782229940887,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000014","name":"Canadian Blood Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>As a result of constrained supply, it is sometimes necessary to provide patients with ABO\u2010mismatched platelets. Such practices increase the risk of acute hemolytic transfusion reaction (AHTR). Providing patients with platelets suspended in O plasma having low\u2010titer Anti\u2010A and Anti\u2010B antibodies (LtABO) could reduce the incidence of AHTR. However, natural scarcity limits the number of such units that can be produced. In this paper we present a study to evaluate strategies for deploying LtABO at regional hospitals in Canada.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Regional hospitals often experience demand for platelets on an irregular basis. They are, however, required to stock some number of platelets (typically one A\u2010unit and one O\u2010unit) for emergencies; outdates are common, with discard rates sometimes &gt;&gt;50%. A simulation study was completed to determine the impact of replacing a (1A, 1O) inventory with 2 or 3\u2009units of LtABO at regional hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant decreases in wastage and shortage can be expected by replacing a (1A, 1O) inventory policy with 2\u2009units of LtABO. In tested cases, a 2\u2010unit LtABO dominated a (1A, 1O) policy, resulting in statistically fewer outdates and instances of shortage. Holding 3\u2009units of LtABO, increases product availability, but results in an increase in outdates when compared to a (1A, 1O) policy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Providing LtABO platelets to smaller, regional hospitals will lower wastage rates and improve patient access to care, when compared to existing (1A, 1O) inventory policies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17418","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T11:59:25Z","timestamp":1685015965000},"page":"1318-1323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating the inventory impact of utilizing low titer platelets in regional hospitals"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0617-8996","authenticated-orcid":false,"given":"John T.","family":"Blake","sequence":"first","affiliation":[{"name":"Department of Industrial Engineering Dalhousie University  Halifax Nova Scotia Canada"},{"name":"Canadian Blood Services  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenn","family":"Clarke","sequence":"additional","affiliation":[{"name":"Canadian Blood Services  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Bodnar","sequence":"additional","affiliation":[{"name":"Canadian Blood Services  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Stepien","sequence":"additional","affiliation":[{"name":"Canadian Blood Services  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01814.x"},{"issue":"8","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1111\/j.1537-2995.2010.02642.x","article-title":"Practices associated with ABO\u2010incompatible platelet transfusions: a BEST Collaborative international survey","volume":"50","author":"Lozano M","journal-title":"Transfusion"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13504"},{"issue":"1","key":"e_1_2_7_5_1","first-page":"612","article-title":"Does ABO and RhD matching matter for platelet transfusion?","volume":"2020","author":"Dunbar N","year":"2020","journal-title":"Hematol ASH Educ Program"},{"issue":"2","key":"e_1_2_7_6_1","first-page":"42","article-title":"Is platelet expiring out of date? 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