{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:38:17Z","timestamp":1789609097906,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autoimmune hemolytic anemia (AIHA) is characterized by humoral and\/or cellular immune\u2010mediated hemolysis of red blood cells. The role of therapeutic plasma exchange (TPE) in AIHA is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We queried the National Inpatient Sample (NIS) for 2002\u20132019 to identify hospitalizations with the primary diagnosis of AIHA. We included hospitalizations with the highest severity subclass identified by All Patient Refined Disease Related Group (APR\u2010DRG). We used multivariate regression analysis to compare in\u2010hospital mortality and other relevant in\u2010hospital outcomes between hospitalizations that received TPE and those that did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 255 weighted hospitalizations in the TPE group and 4973 in the control group. Those in the control group were older (median age 67 vs. 48\u2009years, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and had a higher prevalence of most comorbidities. The TPE group had higher odds of all\u2010cause in\u2010hospital mortality (odds ratio [OR], 1.59; 95% confidence interval [CI], 1.19\u20132.11). They also had higher rates of many secondary outcomes, including requiring mechanical ventilation, developing circulatory shock, acute stroke, urinary tract infections, intracranial hemorrhage, acute kidney injury, and requiring new hemodialysis. No significant differences were noted in the rates of acute myocardial infarctions, bacterial pneumonia, sepsis\/septicemia, thromboembolic events, and other bleeding events. Furthermore, the TPE group had a higher median length of hospital stay (19 vs. 9\u2009days, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hospitalizations with severe AIHA that received TPE had higher rates of adverse in\u2010hospital outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17445","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T07:42:38Z","timestamp":1688370158000},"page":"1376-1383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Outcomes of therapeutic plasma exchange in severe autoimmune hemolytic anemia hospitalizations: An analysis of the National Inpatient Sample"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1277-9600","authenticated-orcid":false,"given":"Ali","family":"Abdelhay","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Rochester General Hospital  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0630-1117","authenticated-orcid":false,"given":"Amir A.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rochester General Hospital  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0303-2652","authenticated-orcid":false,"given":"Omar","family":"Ammari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Henry Ford Hospital  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6813-2956","authenticated-orcid":false,"given":"Rami","family":"Dalbah","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine East Tennessee State University  Johnson City Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouna","family":"Reghis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rochester General Hospital  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Hashem","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rochester General Hospital  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouaz","family":"Alkasem","sequence":"additional","affiliation":[{"name":"School of Medicine University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rochester General Hospital  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12979-020-00208-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S250250"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26213"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2019.100648"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21705"},{"key":"e_1_2_10_7_1","unstructured":"Healthcare Cost and Utilization Project (HCUP).Introduction to the HCUP National Inpatient Sample (NIS) 2019.2019Available from:https:\/\/www.hcup-us.ahrq.gov\/db\/nation\/nis\/NISIntroduction2019.pdf. 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Accessed 14 Jan 2023."}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:57:42Z","timestamp":1708430262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.17445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/trf.17445"],"URL":"https:\/\/doi.org\/10.1111\/trf.17445","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"2023-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}