{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:44:48Z","timestamp":1788345888654,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL126130"],"award-info":[{"award-number":["R01HL126130"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anemia in very low birth weight (VLBW) infants is common and frequently managed with red blood cell (RBC) transfusions. We utilized a linked vein\u2010to\u2010vein database to assess the role of blood donors and component factors on measures of RBC transfusion effectiveness in VLBW infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We linked blood donor and component manufacturing data with VLBW infants transfused RBCs between January 1, 2013 and December 31, 2016 in the Recipient Epidemiology Donor Evaluation Study\u2010III (REDS III) database. Using multivariable regression, hemoglobin increments and subsequent transfusion events following single\u2010unit RBC transfusion episodes were examined with consideration of donor, component, and recipient factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data on VLBW infants (<jats:italic>n<\/jats:italic>\u2009=\u2009254) who received one or more single\u2010unit RBC transfusions (<jats:italic>n<\/jats:italic>\u2009=\u2009567\u2009units) were linked to donor demographic and component manufacturing characteristics for analysis. Reduced post\u2010transfusion hemoglobin increments were associated with RBC units donated by female donors (\u22120.24\u2009g\/dL [95% confidence interval (CI) \u22120.57, \u22120.02]; <jats:italic>p<\/jats:italic>\u2009=\u2009.04) and donors &lt;25\u2009years old (\u22120.57\u2009g\/dL [95% CI \u22121.02, \u22120.11]; <jats:italic>p<\/jats:italic>\u2009=\u2009.02). For RBC units donated by male donors, reduced donor hemoglobin levels were associated with an increased need for subsequent recipient RBC transfusion (odds ratio 3.0 [95% CI 1.3, 6.7]; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). In contrast, component characteristics, storage duration, and time from irradiation to transfusion were not associated with post\u2010transfusion hemoglobin increments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Donor sex, age, and hemoglobin levels were associated with measures of RBC transfusion effectiveness in VLBW infants. Mechanistic studies are needed to better understand the role of these potential donor factors on other clinical outcomes in VLBW infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17468","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T13:08:18Z","timestamp":1688130498000},"page":"1424-1429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Associations of donor, component, and recipient factors on hemoglobin increments following red blood cell transfusion in very low birth weight infants"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3484-790X","authenticated-orcid":false,"given":"Robert A.","family":"DeSimone","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Plimier","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research  Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9653-9905","authenticated-orcid":false,"given":"Ruchika","family":"Goel","sequence":"additional","affiliation":[{"name":"Simmons Cancer Institute, Department of Internal Medicine Southern Illinois University School of Medicine  Springfield Illinois USA"},{"name":"Vitalant, Corporate Medical Affairs  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7928-3132","authenticated-orcid":false,"given":"Jeanne E.","family":"Hendrickson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Pathology and Laboratory Medicine Emory University School of Medicine and Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra D.","family":"Josephson","sequence":"additional","affiliation":[{"name":"Cancer and Blood Disorders Institute Johns Hopkins All Children's Hospital  St. Petersburg Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-5550","authenticated-orcid":false,"given":"Ravi M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology Emory University School of Medicine and Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Sola\u2010Visner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Newborn Medicine Boston Children's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1063-6155","authenticated-orcid":false,"given":"Nareg H.","family":"Roubinian","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research  Oakland California USA"},{"name":"Vitalant Research Institute  San Francisco California USA"},{"name":"Department of Laboratory Medicine University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"LauW.Neonatal and pediatric transfusion: Clinical guide to transfusion. Accessed 17 August 2022."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-40139-5.00081-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13036"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.04.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584300"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000773"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.152598"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15833"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15339"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI133530"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15179"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2450\/2017.0349-16"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017004820"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14998"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.23942"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14233"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T07:47:30Z","timestamp":1694504850000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.17468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,30]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/trf.17468"],"URL":"https:\/\/doi.org\/10.1111\/trf.17468","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,30]]},"assertion":[{"value":"2023-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}