{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:37:24Z","timestamp":1756384644288,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>AL amyloidosis is associated with acquired factor X (FX) deficiency. Experience related to its management is limited to case reports and series using prothrombin complex concentrate, fresh frozen plasma, plasma exchange, recombinant activated factor seven, and desmopressin with limited and variable efficacy. FX concentrate has not been widely used in its management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We report our experience with the perioperative use of FX concentrate (Coagadex) in two patients with AL amyloidosis\u2010associated acquired FX deficiency requiring surgery, using their individual pharmacokinetic studies to manage perioperative hemostasis. Pharmacokinetic studies involved obtaining post\u2010infusion FX activity at 10\u2009min, 2, and 4\u2009h following the administration of FX concentrate to calculate the FX half\u2010life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both patients' plasma FX activity was successfully increased to provide perioperative hemostatic support. Monitoring FX activity post\u2010surgery was also utilized to maintain FX activity levels to prevent post\u2010operative bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pharmacokinetic studies have a useful role in tailoring preoperative FX repletion in patients with AL amyloidosis associated with acquired FX deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17477","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T10:45:59Z","timestamp":1688985959000},"page":"1773-1777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of individual factor X concentrate pharmacokinetic studies in perioperative management of AL amyloidosis\u2010associated acquired factor X deficiency"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7347-1861","authenticated-orcid":false,"given":"Akeem R.","family":"Lewis","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Medicine Mayo Clinic Rochester  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Peffley","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8852-4666","authenticated-orcid":false,"given":"Allan M.","family":"Klompas","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine Mayo Clinic  Rochester Minnesota USA"},{"name":"Special Coagulation Laboratory, Division of Hematopathology, Department of Laboratory Medicine and Pathology Mayo Clinic College of Medicine  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneel A.","family":"Ashrani","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine Mayo Clinic Rochester  Rochester Minnesota USA"},{"name":"Special Coagulation Laboratory, Division of Hematopathology, Department of Laboratory Medicine and Pathology Mayo Clinic College of Medicine  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2012.03.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02183.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.6.1885"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198104023041407"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197707142970203"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-06-724351"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21603"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197911083011907"},{"key":"e_1_2_6_10_1","unstructured":"Food and Drug Administration.COAGADEX.https:\/\/www.fda.gov\/vaccines\u2010blood\u2010biologics\/approved\u2010blood\u2010products\/coagadexPublished 2023. 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