{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:06:12Z","timestamp":1792037172056,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014386","name":"Abbott Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The identification of blood donors at risk of developing low hemoglobin (Hb) and subsequent intervention is expected to reduce donation\u2010induced iron deficiency and low Hb among blood donors. This study explores the effects of ferritin\u2010guided iron supplementation for female first\u2010time donors implemented in four of five administrative regions in Denmark.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We included 45,919 female first\u2010time donors in this study. Hb values were determined in donations of included donors during a 2\u2010year follow\u2010up period. For each region, an intervention group (after implementation) and a control group (before implementation) were defined. The primary outcome was Hb below the donation threshold (7.8\u2009mmol\/L\u2009~\u200912.5\u2009g\/dL) at the time of donation, in the control group, and the intervention group, using logistic regression. The secondary outcome was the number of donations per donor given during the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed a statistically significant decrease in the risk of female first\u2010time donors experiencing a donation with low Hb after ferritin\u2010guided iron supplementation was introduced: Odds ratio, 0.82; 95% confidence interval (CI), 0.71\u20130.95. We found a statistically significant increase in the number of donations per donor during the follow\u2010up period after intervention; rate ratio: 1.05, 95% CI: 1.02\u20131.08.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Ferritin\u2010guided iron supplementation led to a significant reduction in the occurrence of low hemoglobin (Hb) levels among Danish female first\u2010time blood donors. The intervention was additionally associated with an increase in the number of donations per donor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17484","type":"journal-article","created":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T06:40:20Z","timestamp":1689403220000},"page":"1710-1718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The effect of ferritin\u2010guided iron supplementation among Danish female first\u2010time blood donors"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0630-7850","authenticated-orcid":false,"given":"Louise \u00d8rnskov","family":"Drechsler","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Kj\u00e6rgaard","family":"Boldsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus N Denmark"},{"name":"Danish Big Data Centre for Environment and Health (BERTHA) Aarhus University  Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte","family":"Hindhede","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bitten","family":"Aagaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene Holm","family":"Harritsh\u00f8j","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital  Copenhagen \u00d8 Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schwinn","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital  Copenhagen \u00d8 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Epidemiology Research Statens Serum Institut  Copenhagen Denmark"},{"name":"Danish Cancer Society Research Center  Copenhagen Denmark"},{"name":"Department of Haematology Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6220-9414","authenticated-orcid":false,"given":"Klaus","family":"Rostgaard","sequence":"additional","affiliation":[{"name":"Department of Epidemiology 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