{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T07:54:37Z","timestamp":1769673277728,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016645","name":"Shear Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["U24TR001609"],"award-info":[{"award-number":["U24TR001609"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["3R01AI152078\u201001S1"],"award-info":[{"award-number":["3R01AI152078\u201001S1"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["F31DA054849"],"award-info":[{"award-number":["F31DA054849"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016300","name":"Octapharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016300","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W911QY2090012"],"award-info":[{"award-number":["W911QY2090012"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>COVID\u201019 convalescent plasma (CCP) is an important therapeutic option for outpatients at high risk of hospitalization from SARS\u2010CoV\u20102 infection. We assessed the safety of outpatient CCP transfusions administered during clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We analyzed data pertaining to transfusion\u2010related reactions from two randomized controlled trials in the U.S. that evaluated the efficacy of CCP versus control plasma in various ambulatory settings. Multivariable logistic regression was used to assess whether CCP was associated with transfusion reactions, after adjusting for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The combined study reported 79\/1351 (5.9%) adverse events during the transfusion visit, with the majority 62\/1351 (4.6%) characterized by mild, allergic\u2010type findings of urticaria, and\/or pruritus consistent with minor allergic transfusion reactions; the other reported events were attributed to the patients' underlying disease, COVID\u201019, or vasovagal in nature. We found no difference in the likelihood of allergic transfusion reactions between those receiving CCP versus control plasma (adjusted odds ratio [AOR], 0.75; 95% CI, 0.43\u20131.31). Risk of urticaria and\/or pruritus increased with a pre\u2010existing diagnosis of asthma (AOR, 2.33; 95% CI, 1.16\u20134.67). We did not observe any CCP\u2010attributed antibody disease enhancement in participants with COVID\u201019 or increased risk of infection. There were no life\u2010threatening severe transfusion reactions and no patients required hospitalization related to transfusion\u2010associated complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Outpatient plasma administration was safely performed for nearly 1400 participants. CCP is a safe therapeutic option for outpatients at risk of hospitalization from COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17485","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T10:28:53Z","timestamp":1691058533000},"page":"1639-1648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Transfusion reactions associated with <scp>COVID<\/scp>\u201019 convalescent plasma in outpatient clinical trials"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6839-5809","authenticated-orcid":false,"given":"Moises A.","family":"Huaman","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay S.","family":"Raval","sequence":"additional","affiliation":[{"name":"Department of Pathology University of New Mexico School of Medicine  Albuquerque New Mexico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"Paxton","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Wayne State University  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle S.","family":"Mosnaim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy and Immunology NorthShore University Health System  Evanston Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bela","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care Medicine University of Texas Health Science Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shweta","family":"Anjan","sequence":"additional","affiliation":[{"name":"Department of Medicine, 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