{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T12:35:51Z","timestamp":1763728551852},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Patient Blood Management (PBM) is defined as a patient\u2010centered, systematic, evidence\u2010based approach to improve patient outcomes by managing and preserving a patient's own blood, while promoting patient safety and empowerment. As a corollary, it also reduces the utilization of allogeneic blood components. However, demonstrating cost\u2010effectiveness depends on the health insurance system considered. This analysis aims to estimate the one\u2010year budget impact of PBM in four elective surgical areas, from French National Health Insurance and hospital perspectives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A budget impact model was developed to estimate the difference in the cost of care between scenarios with and without PBM. The impact of hematopoiesis optimization (first pillar of PBM) was studied throughout the management of preoperative anemia and iron deficiency in four types of surgeries: orthopedic, cardiac &amp; cardiovascular, vascular &amp; thoracic, and urologic &amp; visceral surgery. Estimation of model's parameters was based on data collected in 10 French hospitals, literature, and on data from the French national medico\u2010administrative database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 980,125 patients were modeled for all four therapeutic areas. Results shows that implementation of a PBM program could generate annual savings up to \u20ac1079\u2009M from the French National Health Insurance perspective (\u20ac1018\u2009M from the hospital perspective), and the sparing of 181,451 red blood cells units per year. The deterministic sensitivity analysis showed that PBM generates savings for both perspectives in most parameters tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Implementing PBM programs could result in important savings for the health care system in France.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17495","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T11:15:25Z","timestamp":1692789325000},"page":"1692-1700","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Management of perioperative iron deficiency anemia as part of patient blood management in France: A budget impact <scp>model\u2010based<\/scp> analysis based on real world data"],"prefix":"10.1111","volume":"63","author":[{"given":"Sigismond","family":"Lasocki","sequence":"first","affiliation":[{"name":"D\u00e9partement Anesth\u00e9sie R\u00e9animation Centre Hospitalier Universitaire d'Angers  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Delahaye","sequence":"additional","affiliation":[{"name":"D\u00e9partement Anesth\u00e9sie R\u00e9animation, Assistance Publique \u2010 H\u00f4pitaux de Marseille h\u00f4pital Sainte\u2010Marguerite  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Fuks","sequence":"additional","affiliation":[{"name":"D\u00e9partement de chirurgie digestive h\u00e9pato\u2010billiaire endocrinienne H\u00f4pital Cochin, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. H.","family":"Savoie","sequence":"additional","affiliation":[{"name":"Service d'Urologie H\u00f4pital d'Instruction des arm\u00e9es Sainte Anne  Toulon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Dussart","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hofmann","sequence":"additional","affiliation":[{"name":"University of Western Australia, Perth, Australia University Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Paubel","sequence":"additional","affiliation":[{"name":"Inserm UMR S 1145 Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1213\/ANE.0000000000005873"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1097\/SLA.0000000000003095"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1016\/j.bpa.2013.02.002"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1093\/bja\/aes139"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1016\/S0140-6736(11)61381-0"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1093\/bja\/aeu098"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1111\/anae.15095"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.1111\/joim.13004"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.1016\/S0140-6736(96)04330-9"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.1016\/j.amjcard.2007.11.072"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1016\/j.bja.2019.09.016"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1001\/jama.2019.0554"},{"unstructured":"WHO.Policy brief: the urgent need to implement patient blood management [monograph on the internet].https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/346655\/9789240035744-eng.pdf?sequence=1&isAllowed=y2021","key":"e_1_2_10_14_1"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.1016\/j.bja.2020.04.087"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_1","DOI":"10.1111\/trf.14006"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_1","DOI":"10.1111\/anae.14816"},{"doi-asserted-by":"publisher","key":"e_1_2_10_18_1","DOI":"10.1213\/ANE.0000000000006362"},{"doi-asserted-by":"publisher","key":"e_1_2_10_19_1","DOI":"10.1111\/anae.13840"},{"doi-asserted-by":"publisher","key":"e_1_2_10_20_1","DOI":"10.1097\/SLA.0000000000001747"},{"doi-asserted-by":"publisher","key":"e_1_2_10_21_1","DOI":"10.1007\/s00384-015-2461-x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_22_1","DOI":"10.1097\/SLA.0000000000001646"},{"doi-asserted-by":"publisher","key":"e_1_2_10_23_1","DOI":"10.1111\/trf.13468"},{"doi-asserted-by":"publisher","key":"e_1_2_10_24_1","DOI":"10.1213\/ANE.0000000000002086"},{"unstructured":"EFS.Rapport d'activit\u00e9 2021. 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