{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:14:08Z","timestamp":1793060048850,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few cases of transfusion\u2010transmitted hepatitis E virus (HEV) have been published in Spain. Here, we describe a well\u2010characterized lookback investigation of a transfusion\u2010transmitted HEV case at the Community Centre for Blood and Tissues of Asturias (Spain).<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>A female patient with chronic myeloid leukemia underwent an allogeneic bone marrow transplant in March 2019 and showed alterations in liver function shortly afterwards. This patient received blood components from 30 different donors in the 3\u2009months before the transplant. Frozen plasma samples from these donations were investigated for the presence of HEV\u2010RNA. One frequent donor was identified as asymptomatic HEV RNA\u2010positive at the time of his whole blood donation. The investigation revealed that this donor's plasma unit, originally intended for the fractionation industry, had a viral RNA concentration of 1.9\u2009\u00d7\u200910<jats:sup>4<\/jats:sup> copies\/mL. HEV RNA was detected initially in the index patient who received the red cell concentrate from this donor 25\u2009days after the transfusion. HEV RNA isolated from both donor and recipient were identified as subtype 3f. The recipient of platelet concentrate (PC), treated with a riboflavin\u2010based pathogen reduction technology (PRT) was not infected, being negative for the presence of HEV IgM, IgG, and HEV RNA before and after the transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case study shows that HEV was transmitted through red cell transfusion to a recipient, while the patient who received riboflavin\/UV light treated PC did not develop signs of infection. A causal relationship between PRT treatment of the PC and the non\u2010transmission of HEV remains to be established.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17498","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T06:10:56Z","timestamp":1692425456000},"page":"1767-1772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Transfusion\u2010transmission of hepatitis E virus through red blood cell transfusion but not through platelet concentrates: A case report from Spain"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9216-6491","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Ojea","sequence":"first","affiliation":[{"name":"Community Centre for Blood and Tissues of Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Seco","sequence":"additional","affiliation":[{"name":"Community Centre for Blood and Tissues of Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Mata","sequence":"additional","affiliation":[{"name":"Community Centre for Blood and Tissues of Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Carmen","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Regional Transfusion Blood Center  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Elena","family":"\u00c1lvarez Arg\u00fcelles","sequence":"additional","affiliation":[{"name":"Department of Virology University Central Hospital of Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Rodr\u00edguez\u2010Fr\u00edas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology University Hospital Vall D'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Quer Sivila","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology University Hospital Vall D'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariadna","family":"Rando Segura","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology University Hospital Vall D'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Garc\u00eda\u2010Gala","sequence":"additional","affiliation":[{"name":"Department of Hematology University Central Hospital of Asturias  Oviedo Spain"},{"name":"Institute for Bio Health Investigation of Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Microbiology University Central Hospital of Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2012.11.026"},{"key":"e_1_2_8_3_1","unstructured":"World Health Organization.Hepatitis E. Available fromhttps:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-e"},{"key":"e_1_2_8_4_1","unstructured":"European Centre for Disease Prevention and Control.ECDC report: 10\u2010fold increase of hepatitis E cases in the EU\/EEA between 2005 and 2015. 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