{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:47:59Z","timestamp":1790419679145,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T00:00:00Z","timestamp":1693008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Paroxysmal cold hemoglobinuria (PCH) is a rare form of autoimmune hemolytic anemia (AIHA), mainly affecting children. The diagnosis and management are challenging due to similarities to other causes for AIHA and limited availability to Donath\u2010Landsteiner (DL) testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>In this single\u2010center retrospective study, we aimed to characterize the clinical presentation and outcomes of PCH patients, defined as having positive Donath\u2010Landsteiner antibodies, compared to a cohort of AIHA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DL\u2010positive patients were observed to have higher lactate dehydrogenase levels and lower reticulocyte counts compared to DL\u2010negative patients, although this was not statistically significant. We also observed that using steroids in DL\u2010positive patients did not significantly impact their recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our findings support the limited published data on PCH patients and further prompt larger multicenter studies to further characterize these patients so that they are more readily identified, especially in centers where DL antibody testing is not readily available.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17520","type":"journal-article","created":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T15:28:47Z","timestamp":1693063727000},"page":"1969-1977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A single center experience for clinical evaluation of paroxysmal cold hemoglobinuria and <scp>Donath\u2010Landsteiner<\/scp> testing"],"prefix":"10.1111","volume":"63","author":[{"given":"Alejandro","family":"Villar\u2010Prados","sequence":"first","affiliation":[{"name":"Department of Medicine. Division of Hematology and Oncology Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abdelmonem","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Stanford Healthcare  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Duda","sequence":"additional","affiliation":[{"name":"Department of Medicine. Division of Hematology and Oncology Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Medicine. Division of Hematology and Oncology Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8634-6410","authenticated-orcid":false,"given":"Muharrem","family":"Yunce","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Stanford Healthcare  Palo Alto California USA"},{"name":"Department of Pathology Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,26]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"458","volume-title":"Acquired immune hemolytic anemias, xviii","author":"Petz LD","year":"1980"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2007.08.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.01.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14128"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000897"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V7.4.387.387"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.1999.11746439"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14032"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-7963(89)70082-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.114561"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01062.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2004.1.48"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000206397"},{"key":"e_1_2_9_15_1","article-title":"A case of childhood severe paroxysmal cold hemoglobinuria with acute renal failure successfully treated with plasma exchange and Eculizumab","volume":"2022","author":"Pelletier J","year":"2022","journal-title":"Case Rep Pediatr"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1309\/LM1E9Z2QZEREPAI"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T09:08:32Z","timestamp":1696410512000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.17520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,26]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/trf.17520"],"URL":"https:\/\/doi.org\/10.1111\/trf.17520","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,26]]},"assertion":[{"value":"2023-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}