{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:58:25Z","timestamp":1782230305391,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:00:00Z","timestamp":1694822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A 4\u2010month\u2010old infant hospitalized since birth received multiple blood transfusions. In March 2022, <jats:italic>Plasmodium falciparum<\/jats:italic> was confirmed with nucleic acid testing. As the mother was assessed as unlikely to be the source of infection, the blood operator initiated a traceback investigation for a potential blood donor source. The patient had received 13 red blood cell (RBC) transfusions (aliquoted from 11 donors), 4 apheresis platelet (PLT) transfusions and 16 buffy coat pooled PLT transfusions. The blood operator medical team developed a supplementary malaria infection risk questionnaire to identify donors at highest risk of life\u2010time malaria infection, based on birthplace, residence, or travel in malaria\u2010endemic regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With 79 donors initially implicated, initial focus was on donors of RBC components. The 11 RBC donors were contacted and assessed using the supplementary questionnaire. Three donors, all of whom met current malaria\u2010related donor eligibility criteria, were deemed high risk of prior malaria infection. These donors consented to <jats:italic>P<\/jats:italic>. <jats:italic>falciparum<\/jats:italic> serology and nucleic acid testing (NAT). One donor who was born and had resided in an endemic West African country for 14\u2009years, was positive for <jats:italic>P<\/jats:italic>. <jats:italic>falciparum<\/jats:italic> by serology (indirect fluorescent antibody test) and NAT\u2010(Ct \u226532). Lookback of this donor's transfused fresh co\u2010components and prior donation identified no other malaria cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This was a probable transfusion\u2010transmitted malaria (TTM) case from an eligible donor who in retrospect was found to have unrecognized, asymptomatic, semi\u2010immune malaria infection, and who was potentially infectious. Blood donor lack of recall of prior malaria infection does not negate the risk of TTM from those who have lived in malaria\u2010endemic countries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17549","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T08:37:38Z","timestamp":1694853458000},"page":"2001-2006","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Canadian Blood Services traceback investigation of a suspected case of transfusion\u2010transmitted malaria"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2178-7562","authenticated-orcid":false,"given":"Bryan","family":"Tordon","sequence":"first","affiliation":[{"name":"Alberta Precision Laboratories (APL)  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2519-1109","authenticated-orcid":false,"given":"Steven 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momar","family":"Ndao","sequence":"additional","affiliation":[{"name":"National Reference Centre for Parasitology, Research Institute of the McGill University Health Centre  Montreal Quebec Canada"},{"name":"Department of Medicine, Division of Infectious Diseases McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Bigham","sequence":"additional","affiliation":[{"name":"Canadian Blood Services  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Seftel","sequence":"additional","affiliation":[{"name":"Canadian Blood Services  Vancouver British Columbia Canada"},{"name":"Department of Medicine University of British Columbia  Vancouver British Columbia 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