{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:16:05Z","timestamp":1784157365429,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The incorporation of anti\u2010CD38 monoclonal antibodies (mAb) in induction regimens of newly diagnosed transplant\u2010eligible multiple myeloma (MM) patients has been established as a new standard. However, the optimal strategy of stem cell mobilization in this context is not yet clear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>From May 2020 till September 2022, we retrospectively reviewed patients receiving anti\u2010CD38 mAb\u2010based induction therapy followed by stem cell mobilization either in a steady\u2010state protocol (SSM) using 10\u2009\u03bcg\/kg granulocyte colony\u2010stimulating factor (G\u2010CSF) for 5\u2009days or in a chemotherapy\u2010based protocol (CM) using 1\u20134\u2009g\/m<jats:sup>2<\/jats:sup> cyclophosphamide and G\u2010CSF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 85 patients (median age 61\u2009years) were included in the analysis. In total, 90 mobilization attempts were performed, 42 with SSM and 48 with CM. There was no significant difference in the median concentration of CD34+ cells in peripheral blood (PB) prior to apheresis between SSM and CM (61\/\u03bcL vs. 55.4\/\u03bcL; <jats:italic>p<\/jats:italic>\u2009=\u2009.60). Cumulative CD34+ yields did not differ between the groups with median of 6.68 and 6.75\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/kg body weight, respectively (<jats:italic>p<\/jats:italic>\u2009=\u2009.35). The target yield (\u22654\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> CD34+ cells\/kg body weight) was reached in 88% (CM) and 86% (SSM), with a high proportion even after a single apheresis session (76% vs. 75%).<\/jats:p><jats:p>Plerixafor was found to be more frequently used in SSM (52%) than in CM (23%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). A total of 83 patients underwent autologous transplantation and all were engrafted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Stem cell collection in patients undergoing anti\u2010CD38\u2010based induction therapy is feasible with either CM or SSM, although SSM more frequently requires plerixafor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17566","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T09:40:01Z","timestamp":1697622001000},"page":"2131-2139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Steady\u2010state versus chemotherapy\u2010based hematopoietic cell mobilization after <scp>anti\u2010CD38<\/scp>\u2010based induction therapy in newly diagnosed multiple myeloma"],"prefix":"10.1111","volume":"63","author":[{"given":"Raphael","family":"Teipel","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I University Hospital Carl Gustav Carus  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Rieprecht","sequence":"additional","affiliation":[{"name":"Department of Hematology, Cellular Therapy, Hemostaseology, and Infectious Diseases University Leipzig Medical Center  Leipzig Germany"},{"name":"Pharmacy University Leipzig Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolin","family":"Trautmann\u2010Grill","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital Carl Gustav Carus  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"R\u00f6llig","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital Carl Gustav Carus  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Kl\u00f6tzer","sequence":"additional","affiliation":[{"name":"Department of Hematology, Cellular Therapy, Hemostaseology, and Infectious Diseases University Leipzig Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital Carl Gustav Carus  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grit","family":"Rathaj","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital Carl Gustav Carus  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Bach","sequence":"additional","affiliation":[{"name":"Department of Hematology, Cellular Therapy, Hemostaseology, and Infectious Diseases University Leipzig Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy","family":"Br\u00fcckner","sequence":"additional","affiliation":[{"name":"Department of Hematology, Cellular Therapy, Hemostaseology, and Infectious Diseases University Leipzig Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Heyn","sequence":"additional","affiliation":[{"name":"Department of Hematology, Cellular Therapy, Hemostaseology, and Infectious Diseases University Leipzig Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song\u2010Yau","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Cellular Therapy, Hemostaseology, and Infectious Diseases University Leipzig Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madlen","family":"Jentzsch","sequence":"additional","affiliation":[{"name":"Department of Hematology, Cellular Therapy, Hemostaseology, and Infectious Diseases University Leipzig Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Schwind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Kretschmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital Carl Gustav Carus  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Egger\u2010Heidrich","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital Carl Gustav Carus  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Remane","sequence":"additional","affiliation":[{"name":"Pharmacy University Leipzig Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg\u2010Nikolaus","family":"Franke","sequence":"additional","affiliation":[{"name":"Department of Hematology, Cellular Therapy, Hemostaseology, and Infectious Diseases University Leipzig Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2995-3230","authenticated-orcid":false,"given":"Malte","family":"von Bonin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital Carl Gustav Carus  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bornh\u00e4user","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital Carl Gustav Carus  Dresden Germany"},{"name":"National Center for Tumor Disease (NCT)  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Platzbecker","sequence":"additional","affiliation":[{"name":"Department of Hematology, Cellular Therapy, Hemostaseology, and Infectious Diseases University Leipzig Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"H\u00f6lig","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital Carl Gustav Carus  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Merz","sequence":"additional","affiliation":[{"name":"Department of Hematology, Cellular Therapy, Hemostaseology, and Infectious Diseases University Leipzig Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-285X","authenticated-orcid":false,"given":"Vladan","family":"Vu\u010dini\u0107","sequence":"additional","affiliation":[{"name":"Department of Hematology, Cellular Therapy, Hemostaseology, and Infectious Diseases University Leipzig Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611750"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30099-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204925"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31240-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005288"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(22)00263-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.10.013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.01.008"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.07.014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21206"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21323"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.11.012"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.39"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2021.06.025"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2020.04.011"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.281610"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-6367(23)00614-0"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.11.029"},{"key":"e_1_2_7_20_1","unstructured":"Beschluss der Bundes\u00e4rztekammer \u00fcber die erste Fortschreibung der Richtlinie zur Herstellung und Anwendung von h\u00e4matopoetischen Stammzellzubereitungen. Deutsches \u00c4rzteblatt.2019."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704781"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.1.1996.5.213"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.104"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.7.1666.1666"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-241737"},{"key":"e_1_2_7_26_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2020"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30206-6"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.261842"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-018-0119-4"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.02.013"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.08.018"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2022.2123229"},{"issue":"12","key":"e_1_2_7_33_1","article-title":"Ciltacabtagene Autoleucel for patients with triple\u2010class exposed multiple myeloma: adjusted comparison of CARTITUDE\u20101 patient outcomes versus real\u2010world clinical practice","volume":"6","author":"Delforge M","year":"2022","journal-title":"Hema"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024850"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204591"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203478"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T15:23:24Z","timestamp":1704209004000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.17566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,18]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/trf.17566"],"URL":"https:\/\/doi.org\/10.1111\/trf.17566","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,18]]},"assertion":[{"value":"2023-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}