{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:24:48Z","timestamp":1791206688017,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Severe T\u2010cell lymphopenia of uncertain clinical significance has been observed in frequent apheresis platelet donors. Two commonly used plateletpheresis instruments are the Trima Accel, which uses a leukoreduction system (LRS) chamber to trap leukocytes and the Fenwal Amicus, which does not use an LRS chamber.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>\n                      We performed an international, multicenter, observational study comparing T\u2010cell populations in frequent platelet donors collected exclusively using the Trima instrument (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009131) or the Amicus instrument (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200977). Age\u2010 and sex\u2010matched whole blood donors (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009126) served as controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CD4\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cell counts &lt;200 cells\/\u03bcL were found in 9.9% of frequent Trima (LRS+) platelet donors, 4.4% of frequent Amicus (LRS\u2212) platelet donors, and 0 whole blood donors (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001). CD4\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cell counts &lt;200 cells\/\u03bcL were only seen in platelet donors with \u2265200 lifetime donations. In multivariable analysis, age, lifetime donations, and instrument (Trima vs. Amicus) were independent risk factors for lymphopenia. In 40 Trima platelet donors, a plasma rinseback procedure was routinely performed following platelet collections. No Trima platelet donors receiving plasma rinseback had a CD4\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cell count &lt;200 cells\/\u03bcL versus 13\/91 Trima platelet donors not receiving plasma rinseback (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Recurrent bulk lymphocyte removal appears to contribute to the development of T\u2010cell lymphopenia in frequent, long\u2010term platelet donors. Lymphopenia is more common when an LRS chamber is used during platelet collection but can occur without an LRS chamber. Blood centers using LRS chambers can mitigate donor lymphopenia by performing plasma rinseback.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.17567","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:22:14Z","timestamp":1697073734000},"page":"2072-2082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Risk factors for T\u2010cell lymphopenia in frequent platelet donors: The\n                    <scp>BEST<\/scp>\n                    collaborative study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0041-804X","authenticated-orcid":false,"given":"Richard M.","family":"Kaufman","sequence":"first","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3674-6934","authenticated-orcid":false,"given":"Denese C.","family":"Marks","sequence":"additional","affiliation":[{"name":"Research and Development Australian Red Cross Lifeblood  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Flamand","sequence":"additional","affiliation":[{"name":"Department of Data Science Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1445-827X","authenticated-orcid":false,"given":"Jason P.","family":"Acker","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8595-8856","authenticated-orcid":false,"given":"Bethany L.","family":"Brown","sequence":"additional","affiliation":[{"name":"American Red Cross Biomedical Services, Medical and Scientific Office  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly","family":"Olafson","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Marschner","sequence":"additional","affiliation":[{"name":"Vitalant  Rosemont Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3614-2353","authenticated-orcid":false,"given":"Suchitra","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine and Stanford Blood Center  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Papari","sequence":"additional","affiliation":[{"name":"Vitalant  Rosemont Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Petraszko","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation Canadian Blood Services  Ottawa Ontario Canada"},{"name":"Department of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Serrano","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-740X","authenticated-orcid":false,"given":"Dawn","family":"Ward","sequence":"additional","affiliation":[{"name":"Wing\u2010Kwai and Alice Lee\u2010Tsing Chung Transfusion Service, Department of Pathology and Laboratory Medicine David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9594-2532","authenticated-orcid":false,"given":"Ren\u00e9e","family":"Bazin","sequence":"additional","affiliation":[{"name":"H\u00e9ma\u2010Qu\u00e9bec, Medical Affairs and Innovation  Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Biomedical Excellence for Safer Transfusion Collaborative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16449"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-09-873125"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16666"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15441"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-017-0006-x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.01.007"},{"issue":"2","key":"e_1_2_7_8_1","first-page":"29A","article-title":"Characterization of residual cell populations in leukoreduction system (LRS) disposable sets following apheresis platelet collections","volume":"62","author":"Kelly K","year":"2022","journal-title":"Transfusion"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100893"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.01033.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002685"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.16526"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16373"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16175"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17037"},{"issue":"2","key":"e_1_2_7_16_1","first-page":"202","article-title":"Immunogenicity of quadrivalent meningococcal conjugate vaccine in frequent platelet donors","volume":"142","author":"Desjardin M","year":"2023","journal-title":"Blood"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2202348"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1992.32192116433.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25817"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12693"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.10084"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20370"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T10:23:12Z","timestamp":1704190992000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.17567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/trf.17567"],"URL":"https:\/\/doi.org\/10.1111\/trf.17567","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,11]]},"assertion":[{"value":"2023-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}