{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:33:34Z","timestamp":1763202814990,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011747","name":"Novo Nordisk Foundation Center for Basic Metabolic Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Turoctocog alfa is a recombinant Factor VIII used in patients with hemophilia A. The aim is to assess the real\u2010life evidence of turoctocog alfa in surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Data were extracted from a national database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Turoctocog alfa was used for 86 surgeries (49 major and 37 minor) in 56 patients. The results are expressed as medians (interquartile range).<\/jats:p><jats:p>Six (10.7%) patients had severe hemophilia A, four (7.1%) moderate, and 46 (82.2%) mild. For patients who underwent major surgeries, basal plasma FVIII coagulant activity (FVIII:C) levels were 15\u2009IU.dL<jats:sup>\u22121<\/jats:sup> (8\u201322). Eight (5\u201314) infusions were given, at a preoperative loading dose of 40.0 (35.0\u201345.5) IU.kg<jats:sup>\u22121<\/jats:sup> and a total dose of 253.3 (125.0\u2013507.0) IU.kg<jats:sup>\u22121<\/jats:sup>. In patients who underwent minor surgeries, basal FVIII:C levels were 18\u2009IU.dL<jats:sup>\u22121<\/jats:sup> (9\u201331). Two (1\u20133) infusions were required, at a preoperative loading dose of 34.0 (28.8\u201338.5) IU.kg<jats:sup>\u22121<\/jats:sup> and a total dose of 73.7 (37.6\u2013122.1) IU.kg<jats:sup>\u22121<\/jats:sup>. The overall clinical efficacy was judged excellent\/good in 77 procedures (89.5%) and fair\/poor in nine (10.5%). The fair\/poor efficacy concerned seven patients (six mild hemophilia and one severe), for four urological surgeries, two dermatological procedures, one heart surgery, one ear\u2010nose\u2010throat procedure, and one dental avulsion in the patient with severe hemophilia. Three out of those seven patients received antiplatelet therapy. No thromboembolic events, anti\u2010FVIII antibodies, or adverse events were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The efficacy and safety of turoctocog alfa were confirmed for the management of surgery in patients with hemophilia A. No adverse events were observed and overall efficacy was good.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17576","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T11:29:20Z","timestamp":1697628560000},"page":"2321-2327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and safety of turoctocog alfa in patients with hemophilia A requiring surgical procedures: A multicentre retrospective study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6500-5190","authenticated-orcid":false,"given":"Nicolas","family":"Drillaud","sequence":"first","affiliation":[{"name":"CHU Nantes, Centre de Ressources et de Comp\u00e9tences des Maladies H\u00e9morragiques Constitutionnelles Nantes Universit\u00e9  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Cussac","sequence":"additional","affiliation":[{"name":"Centre de Traitement des Maladies H\u00e9morragiques Constitutionnelles CH Le Mans  Le Mans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Olivier","family":"Bertho","sequence":"additional","affiliation":[{"name":"CHU Nantes, Centre de Ressources et de Comp\u00e9tences des Maladies H\u00e9morragiques Constitutionnelles Nantes Universit\u00e9  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2988-5952","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Horvais","sequence":"additional","affiliation":[{"name":"CHU Nantes, Unit\u00e9 d'Investigation Clinique 17 Nantes Universit\u00e9  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Beurrier","sequence":"additional","affiliation":[{"name":"Centre de Traitement des Maladies H\u00e9morragiques Constitutionnelles CHU Angers  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Ternisien","sequence":"additional","affiliation":[{"name":"CHU Nantes, Centre de Ressources et de Comp\u00e9tences des Maladies H\u00e9morragiques Constitutionnelles Nantes Universit\u00e9  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann","family":"Rose","sequence":"additional","affiliation":[{"name":"Centre de Traitement des Maladies H\u00e9morragiques Constitutionnelles CH Le Mans  Le Mans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Fouassier","sequence":"additional","affiliation":[{"name":"CHU Nantes, Centre de Ressources et de Comp\u00e9tences des Maladies H\u00e9morragiques Constitutionnelles Nantes Universit\u00e9  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-7094","authenticated-orcid":false,"given":"Antoine","family":"Babuty","sequence":"additional","affiliation":[{"name":"CHU Nantes, Centre de Ressources et de Comp\u00e9tences des Maladies H\u00e9morragiques Constitutionnelles Nantes Universit\u00e9  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Trossa\u00ebrt","sequence":"additional","affiliation":[{"name":"CHU Nantes, Centre de Ressources et de Comp\u00e9tences des Maladies H\u00e9morragiques Constitutionnelles Nantes Universit\u00e9  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12672"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5482\/HAMO-15-06-0019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12159"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13617"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12165"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12518"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2200089"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-018-2415-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029617715117"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14388"},{"journal-title":"Haemophilia","article-title":"Surgical outcomes in patients with haemophilia a or B receiving extended half\u2010life recombinant factor VIII and IX fc fusion proteins: real\u2010world experience in the Nordic countries","author":"Lehtinen 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