{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:57:23Z","timestamp":1784959043046,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The burden of transfusion\u2010transmitted infections among blood recipients remains low due to extensive pre\u2010 and post\u2010donation screening. However, the military has the unique challenge of providing blood in austere environments with limited testing capabilities. This study evaluates the infectious etiologies of deferred blood donors at a large military blood donation center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All blood donors at the Armed Service Blood Bank Center, San Antonio, between 2017 and 2022 with positive post\u2010donation screening for hepatitis C (HCV), hepatitis B (HBV), human immunodeficiency virus (HIV), human T\u2010lymphotropic virus (HTLV\u2010I\/II), Zika (2018\u20132021), West Nile virus, <jats:italic>Trypanosoma cruzi<\/jats:italic>, <jats:italic>Treponema pallidum<\/jats:italic>, or <jats:italic>Babesia microti<\/jats:italic> (2020\u20132022) were evaluated. Donors were deferred based on Food and Drug Administration (FDA) guidance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two\u2010hundred and thirteen (213) donors met FDA criteria for deferral. <jats:italic>T. pallidum<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u200945, 50.3 per 100,000), HCV (<jats:italic>n<\/jats:italic>\u2009=\u200934, 38.0 per 100,000), and HBV (<jats:italic>n<\/jats:italic>\u2009=\u200919, 21.2 per 100,000) were the most common pathogens among those with both positive screening and confirmatory testing. The majority of HIV (95%), Chagas (78%), HTLV\u2010I\/II (50%) deferrals were due to indeterminate confirmatory tests following initial positive screens. The majority of deferrals for HBV were for a second occurrence of a positive screen despite negative confirmatory testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rates of post\u2010donation deferral for transfusion\u2010transmissible infections were low in this military cohort. Our findings suggest that donor testing in deployed service members should focus on HBV, HCV, and <jats:italic>T. pallidum<\/jats:italic> and highlight the need for better diagnostics for HIV, Chagas, and HTLV\u2010I\/II.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17584","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T10:35:19Z","timestamp":1697625319000},"page":"2265-2272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Infectious etiologies among <scp>post\u2010donation<\/scp> deferrals in a military blood donation center"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3847-3036","authenticated-orcid":false,"given":"Somin","family":"Kwon","sequence":"first","affiliation":[{"name":"School of Medicine Uniformed Services University of the Health Sciences  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian G.","family":"Casleton","sequence":"additional","affiliation":[{"name":"Armed Services Blood Bank Center\u2010San Antonio, Joint Base San Antonio\u2010Lackland  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glorimar Z.","family":"Rivera","sequence":"additional","affiliation":[{"name":"Armed Services Blood Bank Center\u2010San Antonio, Joint Base San Antonio\u2010Lackland  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melita M.","family":"Gella","sequence":"additional","affiliation":[{"name":"Armed Services Blood Bank Center\u2010San Antonio, Joint Base San Antonio\u2010Lackland  San Antonio Texas USA"},{"name":"Department of Veterans Affairs Audie Murphy VA Hospital  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin L.","family":"Winkler","sequence":"additional","affiliation":[{"name":"Trainee Health Surveillance, Joint Base San Antonio\u2010Lackland  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Kieffer","sequence":"additional","affiliation":[{"name":"Trainee Health Surveillance, Joint Base San Antonio\u2010Lackland  San Antonio Texas USA"},{"name":"Department of Preventive Medicine and Biostatistics Uniformed Services University of the Health Sciences  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela B.","family":"Osuna","sequence":"additional","affiliation":[{"name":"Trainee Health Surveillance, Joint Base San Antonio\u2010Lackland  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa M.","family":"Casey","sequence":"additional","affiliation":[{"name":"Trainee Health Surveillance, Joint Base San Antonio\u2010Lackland  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather C.","family":"Yun","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine Brooke Army Medical Center, Joint Base San Antonio\u2010Fort Sam Houston  Fort Sam Houston Texas USA"},{"name":"Department of Medicine Uniformed Services University of the Health Sciences  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1789-603X","authenticated-orcid":false,"given":"Joseph E.","family":"Marcus","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine Brooke Army Medical Center, Joint Base San Antonio\u2010Fort Sam Houston  Fort Sam Houston Texas USA"},{"name":"Department of Medicine Uniformed Services University of the Health Sciences  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2011.213"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"S167","article-title":"The U.S. Armed Services Blood Program support to U.S. Central Command 2014\u20102021: transformation of combat trauma resuscitation through blood product innovation and expansion of blood availability far forward","volume":"62","author":"Taylor AL","year":"2022","journal-title":"Transfusion"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000003268"},{"key":"e_1_2_8_5_1","volume-title":"Whole blood transfusion (CPG ID: 21)","author":"Joint Trauma System","year":"2018"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02906.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12101"},{"key":"e_1_2_8_8_1","unstructured":"AABB.Blood Donor History Questionnaires.2023[cited 2023 June 15]. 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