{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:43:07Z","timestamp":1780105387126,"version":"3.54.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hemolytic disease of the newborn (HDN) occurs in approximately 1 out of 3000 live births. Severe presentations are atypical but must be recognized and treated rapidly to avoid life\u2010threatening organ dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>Here we report an unusual case of neonatal ABO HDN that illustrates the enormous inflammatory potential of maternal\u2010fetal blood group mismatch. Following an uneventful delivery notable only for HDN caused by maternal anti\u2010B IgG, our patient developed shock, DIC, and renal failure. Despite numerous interventions, she experienced a rapid clinical decline and died 10\u2009days after birth. Treatment with whole blood exchange and a monoclonal antibody directed at complement component 5 (eculizumab) were attempted late in the disease course but were unsuccessful. Importantly, this patient had several known risk factors for severe ABO HDN, including the pentad of a group O mother with a group B neonate, high newborn red blood cell B antigen expression, presence maternal anti\u2010B isohemagglutinin in high titer, presence of a maternal IgG anti\u2010B isohemagglutinin, and African ancestry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinicians should be aware of the potential for severe ABO HDN and consider earlier diagnostic workup and more aggressive therapy in patients with high\u2010risk features.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17614","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T07:50:08Z","timestamp":1702108208000},"page":"185-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fatal hemolytic disease of the newborn due to <scp>anti\u2010B<\/scp> Isohemagglutinin: An unfamiliar presentation of a familiar disease"],"prefix":"10.1111","volume":"64","author":[{"given":"Mckenna","family":"Longacre","sequence":"first","affiliation":[{"name":"Department of Anesthesia Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0754-7688","authenticated-orcid":false,"given":"Pavan K.","family":"Bendapudi","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of Hematology and Blood Transfusion Service Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Division of Hemostasis and Thrombosis Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2014.34.3.223"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.78.3.F220"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2005.00549.x"},{"key":"e_1_2_7_5_1","first-page":"205","article-title":"Severe hemolytic disease of the newborn in a group B African\u2010American infant delivered by a group O mother","volume":"36","author":"Drabik\u2010Clary K","year":"2006","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1999-6820"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.076794"},{"key":"e_1_2_7_8_1","first-page":"165","volume-title":"Pathophysiology of hemolytic transfusion reactions seminars in hematology","author":"Davenport RD","year":"2005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1309\/VXY1ULAFUY6E6JT3"},{"key":"e_1_2_7_10_1","first-page":"1117","article-title":"The existence of atypical blood group galactosyltransferase which causes an expression of A2 character in A1B red blood cells","volume":"35","author":"Yoshida A","year":"1983","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.007229"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-732800"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T09:03:45Z","timestamp":1705914225000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.17614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,8]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/trf.17614"],"URL":"https:\/\/doi.org\/10.1111\/trf.17614","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,8]]},"assertion":[{"value":"2023-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}