{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:30:26Z","timestamp":1790375426136,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN 75N92019D00032"],"award-info":[{"award-number":["HHSN 75N92019D00032"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN 75N92019D00033"],"award-info":[{"award-number":["HHSN 75N92019D00033"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The safety of transfusion of SARS\u2010CoV\u20102 antibodies in high plasma volume blood components to recipients without COVID\u201019 is not established. We assessed whether transfusion of plasma or platelet products during periods of increasing prevalence of blood donor SARS\u2010CoV\u20102 infection and vaccination was associated with changes\u00a0in outcomes in hospitalized patients without COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study of hospitalized adults who received plasma or platelet transfusions at 21 hospitals during pre\u2010COVID\u201019 (3\/1\/2018\u20132\/29\/2020), COVID\u201019 pre\u2010vaccine (3\/1\/2020\u20132\/28\/2021), and COVID\u201019 post\u2010vaccine (3\/1\/2021\u20138\/31\/2022) study periods. We used multivariable logistic regression with generalized estimating equations to adjust for demographics and comorbidities to calculate odds ratios (ORs) and 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 21,750 hospitalizations of 18,584 transfusion recipients without COVID\u201019, there were 697 post\u2010transfusion thrombotic events, and oxygen requirements were increased in 1751 hospitalizations. Intensive care unit length of stay (<jats:italic>n<\/jats:italic>\u2009=\u200911,683) was 3\u2009days (interquartile range 1\u20135), hospital mortality occurred in 3223 (14.8%), and 30\u2010day rehospitalization in 4144 (23.7%). Comparing the pre\u2010COVID, pre\u2010vaccine and post\u2010vaccine study periods, there were no trends in thromboses (OR 0.9 [95% CI 0.8, 1.1]; <jats:italic>p<\/jats:italic>\u2009=\u2009.22) or oxygen requirements (OR 1.0 [95% CI 0.9, 1.1]; <jats:italic>p<\/jats:italic>\u2009=\u2009.41). In parallel, there were no trends across study periods for ICU length of stay (<jats:italic>p<\/jats:italic>\u2009=\u2009.83), adjusted hospital mortality (OR 1.0 [95% CI 0.9\u20131.0]; <jats:italic>p<\/jats:italic>\u2009=\u2009.36), or 30\u2010day rehospitalization (<jats:italic>p<\/jats:italic>\u2009=\u2009.29).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Transfusion of plasma and platelet blood components collected during the pre\u2010vaccine and post\u2010vaccine periods of the COVID\u201019 pandemic was not associated with increased adverse outcomes in transfusion recipients without COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17616","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T18:21:00Z","timestamp":1701886860000},"page":"53-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical outcomes in hospitalized plasma and platelet transfusion recipients prior to and following widespread blood donor <scp>SARS\u2010CoV<\/scp>\u20102 infection and vaccination"],"prefix":"10.1111","volume":"64","author":[{"given":"Nareg H.","family":"Roubinian","sequence":"first","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research  Oakland California USA"},{"name":"Vitalant Research Institute  San Francisco California USA"},{"name":"Department of Laboratory Medicine UCSF  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0859-6828","authenticated-orcid":false,"given":"John","family":"Greene","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research  Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent X.","family":"Liu","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research  Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lee","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research  Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin G.","family":"Mark","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research  Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Vinson","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Northern California Division of Research  Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9008-9154","authenticated-orcid":false,"given":"Bryan R.","family":"Spencer","sequence":"additional","affiliation":[{"name":"American Red Cross, Scientific Affairs  Dedham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5898-8168","authenticated-orcid":false,"given":"Roberta","family":"Bruhn","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute  San Francisco California USA"},{"name":"Department of Laboratory Medicine UCSF  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Bravo","sequence":"additional","affiliation":[{"name":"Vitalant  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mars","family":"Stone","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute  San Francisco California USA"},{"name":"Department of Laboratory Medicine UCSF  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6251-366X","authenticated-orcid":false,"given":"Brian","family":"Custer","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute  San Francisco California USA"},{"name":"Department of Laboratory Medicine UCSF  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Kleinman","sequence":"additional","affiliation":[{"name":"University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Busch","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute  San Francisco California USA"},{"name":"Department of Laboratory Medicine UCSF  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0526-2088","authenticated-orcid":false,"given":"Philip J.","family":"Norris","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute  San Francisco California USA"},{"name":"Department of Laboratory Medicine UCSF  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the NHLBI Recipient Epidemiology and Donor Evaluation Study\u2010IV\u2010P 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