{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:28:48Z","timestamp":1784014128378,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prehospital low\u2010titer group O whole blood (LTOWB) used for patients with life\u2010threatening hemorrhage is often RhD positive. The most important complication following RhD alloimmunization is hemolytic disease of the fetus and newborn (HDFN). Preceding clinical use of RhD positive LTOWB, we estimated the risk of HDFN due to LTOWB prehospital transfusion in the Finnish population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We collected data on prehospital transfusions in Tampere and Helsinki University Hospital areas. Using the mean of reported alloimmunization rates in trauma studies (24%) and a higher reported rate representing trauma patients of 13\u201350\u2009years old (42.7%), we estimated the risk of HDFN and extrapolated it to the whole of Finland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We estimated that in Finland, with the current prehospital transfusion rate we would see 1\u20133 cases of severe HDFN due to prehospital LTOWB transfusions every 10\u2009years, and fetal death due to HDFN caused by LTOWB transfusion less than once in 100\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The estimated risk of serious HDFN due to prehospital LTOWB transfusion in the Finnish population is similar to previous estimates. As Finland routinely screens expectant mothers for red blood cell antibodies and as the contemporary treatment of HDFN is very effective, we support the prehospital use of RhD positive LTOWB in all patient groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17700","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T10:09:30Z","timestamp":1705658970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Low titer group O whole blood and risk of <scp>RhD<\/scp> alloimmunization: Rationale for use in Finland"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5131-0656","authenticated-orcid":false,"given":"Sanna","family":"Susila","sequence":"first","affiliation":[{"name":"Finnish Red Cross Blood Service  Vantaa Finland"},{"name":"Emergency Medical Service and Emergency Department P\u00e4ij\u00e4t\u2010H\u00e4me wellbeing services county  Lahti Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8469-4091","authenticated-orcid":false,"given":"Minna","family":"Ilmakunnas","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service  Vantaa Finland"},{"name":"Department of Anesthesiology and Intensive Care Medicine Helsinki University Hospital and University of Helsinki  Helsinki Finland"},{"name":"Meilahti Hospital Blood Bank, Department of Clinical Chemistry, HUS Diagnostic Center Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouni","family":"Lauronen","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service  Vantaa Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauli","family":"Vuorinen","sequence":"additional","affiliation":[{"name":"Emergency Medical Services, Centre for Prehospital Emergency Care Pirkanmaa wellbeing services county  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"\u00c5ngerman","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Services Helsinki University Hospital and University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Sainio","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service  Vantaa Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17480"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2019.06.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/XCS.0000000000000086"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15696"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16528"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00031348211049752"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13357"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14012"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14547"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12495"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000414"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12265"},{"key":"e_1_2_6_14_1","first-page":"1","article-title":"Recommendations on the use of group O red blood cells [Internet]","author":"Murphy M","year":"2019","journal-title":"AABB Association Bulletin #19\u201302"},{"key":"e_1_2_6_15_1","unstructured":"National Blood Transfusion Committee.The appropriate use of group O D negative red cells [Internet]. NHS Blood and Transplant.2019[cited 2023 Nov 28]. 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