{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:04:09Z","timestamp":1784761449566,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009210","name":"Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009210","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006438","name":"Office of the Assistant Secretary for Health","doi-asserted-by":"publisher","award":["75F40120C00101"],"award-info":[{"award-number":["75F40120C00101"]}],"id":[{"id":"10.13039\/100006438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>HIV, HBV, and HCV infections for ~60% of the US blood supply are monitored by TTIMS with syphilis added in 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Data were compiled from October 2020 to September 2022. Syphilis prevalence was estimated for allogeneic and directed donors who were consensus positive (CP) and the subset of those with confirmed\u2010active infections (AI). Prevalence and incidence were stratified by demographics for two consecutive 1\u2010year periods, starting October 1, 2020 and for both years combined. Incidence was estimated for repeat donors. Associations between syphilis positivity and other infections were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 14.75 million donations, syphilis prevalence was 28.4\/100,000 donations and significantly higher during the second year compared to the first year. Overall, syphilis incidence for the two\u2010year period was 10.8\/100,000 person\u2010years. The adjusted odds of a CP infection were 1.18 (95% CI: 1.11, 1.26) times higher in the second year compared to the first, and for AI, 1.22 (95% CI: 1.10, 1.35) times higher in year 2. Highest rates occurred among males, first\u2010time, Black, and younger (ages 18\u201339) donors, and those in the South US Census region. Syphilis CP donors were 64 (95% CI: 46, 89) times more likely to be HIV CP, and AI donors 77 (95% CI: 52, 114) times more likely to be HIV CP than non\u2010CP donors, when controlling for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary\/Conclusions<\/jats:title><jats:p>Syphilis prevalence increased over the study period mirroring national trends reported by CDC and is significantly associated with HIV CP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17707","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T11:53:55Z","timestamp":1704455635000},"page":"325-333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Syphilis seroprevalence and incidence in <scp>US<\/scp> blood donors from 2020 to 2022"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2507-9141","authenticated-orcid":false,"given":"Galen","family":"Conti","sequence":"first","affiliation":[{"name":"American Red Cross Scientific Affairs  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward P","family":"Notari","sequence":"additional","affiliation":[{"name":"American Red Cross Scientific Affairs  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger Y.","family":"Dodd","sequence":"additional","affiliation":[{"name":"American Red Cross Scientific Affairs  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Kessler","sequence":"additional","affiliation":[{"name":"New York Blood Center Enterprises  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6251-366X","authenticated-orcid":false,"given":"Brian","family":"Custer","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute  San Francisco California USA"},{"name":"Department of Laboratory Medicine University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Reik","sequence":"additional","affiliation":[{"name":"OneBlood  St. Petersburg Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4213-5013","authenticated-orcid":false,"given":"Marion C.","family":"Lanteri","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of California San Francisco  San Francisco California USA"},{"name":"Creative Testing Solutions  Tempe Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benyam","family":"Hailu","sequence":"additional","affiliation":[{"name":"US National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yang","sequence":"additional","affiliation":[{"name":"US Food and Drug Administration  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5865-6366","authenticated-orcid":false,"given":"Susan L.","family":"Stramer","sequence":"additional","affiliation":[{"name":"American Red Cross Scientific Affairs  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the U.S. Transfusion\u2010Transmissible Infections Monitoring System (TTIMS)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"173","volume-title":"Technical manual","author":"Crowder LA","year":"2020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00023.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16005"},{"key":"e_1_2_9_5_1","unstructured":"PK7400 TP HA REAGENT Instructions for Use.Creative testing solutions.https:\/\/www.mycts.org\/Portals\/0\/Assay_PI\/WholeBlood\/Syphilis.pdf"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.10.3233-3234.1999"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.CPJ.0000435752.17621.48"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16250"},{"key":"e_1_2_9_9_1","unstructured":"Sexually Transmitted Disease Surveillance 2021.US Centers for Disease Control and Prevention.https:\/\/www.cdc.gov\/std\/statistics\/2021\/figures.htm"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.03055.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.02042.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17393"},{"key":"e_1_2_9_13_1","unstructured":"Revised recommendations for reducing the risk of human immunodeficiency virus transmission by blood and blood products. US Food and Drug Administration.https:\/\/collections.nlm.nih.gov\/catalog\/nlm:nlmuid-9918227270706676-pdf"},{"key":"e_1_2_9_14_1","unstructured":"Recommendations for Evaluating Donor Eligibility Using Individual Risk\u2010Based Questions to Reduce the Risk of Human Immunodeficiency Virus Transmission by Blood and Blood Products. US Food and Drug Administration.https:\/\/www.fda.gov\/regulatory\u2010information\/search\u2010fda\u2010guidance\u2010documents\/recommendations\u2010evaluating\u2010donor\u2010eligibility\u2010using\u2010individual\u2010risk\u2010based\u2010questions\u2010reduce\u2010risk\u2010human"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T08:44:49Z","timestamp":1708505089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.17707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,5]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/trf.17707"],"URL":"https:\/\/doi.org\/10.1111\/trf.17707","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,5]]},"assertion":[{"value":"2023-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}