{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:10:06Z","timestamp":1790655006216,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012399","name":"Biomedical Advanced Research and Development Authority","doi-asserted-by":"publisher","award":["HSO100201600002C"],"award-info":[{"award-number":["HSO100201600002C"]}],"id":[{"id":"10.13039\/100012399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Mirasol\u00ae Pathogen Reduction Technology System was developed to reduce transfusion\u2010transmitted diseases in platelet (PLT) products.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>MiPLATE trial was a prospective, multicenter, controlled, randomized, non\u2010inferiority (NI) study of the clinical effectiveness of conventional versus Mirasol\u2010treated Apheresis PLTs in participants with hypoproliferative thrombocytopenia. The novel primary endpoint was days of \u2265Grade 2 bleeding with an NI margin of 1.6.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 330 participants were randomized, a planned interim analysis of 297 participants (145 MIRASOL, 152 CONTROL) receiving \u22651 study transfusion found a 2.79\u2010relative rate (RR) in the MIRASOL compared to the CONTROL in number of days with \u2265Grade 2 bleeding (95% confidence interval [CI] 1.67\u20134.67). The proportion of subjects with \u2265Grade 2 bleeding was 40.0% (<jats:italic>n<\/jats:italic>\u2009=\u200958) in MIRASOL and 30.3% (<jats:italic>n<\/jats:italic>\u2009=\u200946) in CONTROL (RR\u2009=\u20091.32, 95% CI 0.97\u20131.81, <jats:italic>p<\/jats:italic>\u2009=\u2009.08). Corrected count increments were lower (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01) and the number of PLT transfusion episodes per participant was higher (RR\u2009=\u20091.22, 95% CI 1.05\u20131.41) in MIRASOL. There was no difference in the days of PLT support (hazard ratio\u2009=\u20090.86, 95% CI 0.68\u20131.08) or total number of red blood cell transfusions (RR\u2009=\u20091.12, 95% CI 0.91\u20131.37) between MIRASOL versus CONTROL. Transfusion emergent adverse events were reported in 119 MIRASOL participants (84.4%) compared to 133 (82.6%) participants in CONTROL (<jats:italic>p<\/jats:italic>\u2009=\u2009NS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study did not support that MIRASOL was non\u2010inferior compared to conventional platelets using the novel endpoint number of days with \u2265Grade 2 bleeding in MIRASOL when compared to CONTROL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17720","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T09:57:46Z","timestamp":1707299866000},"page":"457-465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Results of clinical effectiveness of conventional versus Mirasol\u2010treated Apheresis Platelets in Patients with Hypoproliferative Thrombocytopenia (<scp>MiPLATE<\/scp>) trial"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5529-7054","authenticated-orcid":false,"given":"Scott A.","family":"Koepsell","sequence":"first","affiliation":[{"name":"Department of Pathology and Microbiology University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2866-1674","authenticated-orcid":false,"given":"Moritz","family":"Stolla","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Sedjo","sequence":"additional","affiliation":[{"name":"Clinical Research and Development, Terumo BCT, Inc.  Lakewood Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5466-2833","authenticated-orcid":false,"given":"Jeffrey","family":"Carson","sequence":"additional","affiliation":[{"name":"Department of Medicine Robert Wood Johnson Medical School  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3964-5466","authenticated-orcid":false,"given":"Michael","family":"Knudson","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Iowa Carver College of Medicine  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Cook","sequence":"additional","affiliation":[{"name":"Lifetime Scientific Inc.  Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8692-4041","authenticated-orcid":false,"given":"Ross","family":"Fasano","sequence":"additional","affiliation":[{"name":"Center for Transfusion and Cellular Therapies Department of Pathologyand Laboratory Medicine, Emory University School of Medicine  Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha G.","family":"Ngamsuntikul","sequence":"additional","affiliation":[{"name":"South Texas Blood and Tissue  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9847-0470","authenticated-orcid":false,"given":"Claudia","family":"Cohn","sequence":"additional","affiliation":[{"name":"Laboratory Medicine and Pathology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jed","family":"Gorlin","sequence":"additional","affiliation":[{"name":"Memorial Blood Centers  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1089-5787","authenticated-orcid":false,"given":"Meghan","family":"Delaney","sequence":"additional","affiliation":[{"name":"Department of Pathology Children's National Hospital and The George Washington University School of Medicine  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherrill","family":"Slichter","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Ness","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8730-3981","authenticated-orcid":false,"given":"Jeffrey","family":"McCullough","sequence":"additional","affiliation":[{"name":"Laboratory Medicine and Pathology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12502"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2022.09.070"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2005.00736.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02126.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12079"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12945"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01094.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02347.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14042"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-02-831289"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16747"},{"key":"e_1_2_9_13_1","volume-title":"Mirasol disposable kit. 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