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Initially PLER was investigated in placebo\u2010controlled trials with the granulocyte colony\u2010stimulating factor (G\u2010CSF) filgrastim. It has also been used in combination with chemotherapy plus G\u2010CSF in patients who had failed a previous mobilization attempt or appeared to mobilize poorly with current mobilization (preemptive use). This review summarizes what is known regarding addition of PLER to standard mobilization regimens. PLER increases mobilization of CD34<jats:sup>+<\/jats:sup> cells, decreases the number of apheresis sessions needed to achieve collection targets and increases the proportion of patients who can proceed to AHCT. It appears also to increase the amount of various lymphocyte subsets in the grafts collected. In general, hematologic recovery after AHCT has been comparable to patients mobilized without PLER, although slower platelet recovery has been observed in some studies of patients who mobilize poorly. In phase III studies, long\u2010term outcome has been comparable to patients mobilized without PLER. This also appears to be the case in patients receiving plerixafor for poor or suboptimal mobilization of CD34<jats:sup>+<\/jats:sup> cells. In practice, PLER is safe and has not been shown to increase tumor cell mobilization.<\/jats:p>","DOI":"10.1111\/trf.17755","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T12:25:04Z","timestamp":1708950304000},"page":"742-750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of plerixafor use in the mobilization of blood grafts for autologous hematopoietic cell transplantation"],"prefix":"10.1111","volume":"64","author":[{"given":"Esa","family":"Jantunen","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine University of Eastern Finland  Kuopio Finland"},{"name":"Department of Medicine Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Turunen","sequence":"additional","affiliation":[{"name":"Department of Medicine Kuopio University Hospital  Kuopio 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