{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:28:48Z","timestamp":1784014128783,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["2KL2TR002015\u201005A1"],"award-info":[{"award-number":["2KL2TR002015\u201005A1"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["5KL2TR002015\u201006"],"award-info":[{"award-number":["5KL2TR002015\u201006"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100024731","name":"AABB Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100024731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Using low titer group O whole blood (LTOWB) is increasingly popular for resuscitating trauma patients. LTOWB is often RhD\u2010positive, which might cause D\u2010alloimmunization and hemolytic disease of the fetus and newborn (HDFN) if transfused to RhD\u2010negative females of childbearing potential (FCP). This simulation determined the number of life years gained by the FCP and her future children if she was resuscitated with LTOWB compared with conventional component therapy (CCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The model simulated 500,000 injured FCPs of each age between 0 and 49\u2009years with LTOWB mortality relative reductions (MRRs) compared with components between 0.1% and 25%. For each surviving FCP, number of life years gained was calculated using her age at injury and average life expectancy for American women. The number of expected future pregnancies for FCPs that did not survive was also based on her age at injury; each future child was assigned the maximum lifespan unless they suffered perinatal mortality or serious neurological events from HDFN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The LTOWB group with an MRR 25% compared with CCT had the largest total life years gained. The point of equivalence for RhD\u2010positive LTOWB compared to CCT, where life years lost due to severe HDFN was equivalent to life years gained due to FCP survival\/future childbearing, occurred at an MRR of approximately 0.1%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this model, RhD\u2010positive LTOWB resulted in substantial gains in maternal and child life years compared with CCT. A &gt;0.1% relative mortality reduction from LTOWB offset the life years lost to HDFN mortality and severe neurological events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17767","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T08:14:20Z","timestamp":1708935260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Maternal and child life years gained by transfusing low titer group O whole blood in trauma: A computer simulation"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6740-2758","authenticated-orcid":false,"given":"Mark H.","family":"Yazer","sequence":"first","affiliation":[{"name":"Department of Pathology University of Pittsburgh  Pittsburgh Pennsylvania 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