{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:38:36Z","timestamp":1771486716257,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["447352"],"award-info":[{"award-number":["447352"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The CONvalescent Plasma for Hospitalized Adults With COVID\u201019 Respiratory Illness (CONCOR\u20101) trial was a multicenter randomized controlled trial assessing convalescent plasma in hospitalized COVID\u201019 patients. This study evaluates the cost\u2010effectiveness of convalescent plasma and its impact on quality\u2010of\u2010life to provide insight into its potential as an alternative treatment in resource\u2010constrained settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individual patient data on health outcomes and resource utilization from the CONCOR\u20101 trial were used to conduct the analysis from the Canadian public payer's perspective with a time horizon of 30\u2009days post\u2010randomization. Baseline and 30\u2010day EQ\u20105D\u20105L were measured to calculate quality\u2010adjusted survival. All costs are presented in 2021 Canadian dollars. The base case assessed the EQ\u20105D\u20105L scores of hospitalized inpatients reporting at both timepoints, and a utility score of 0 was assigned for patients who died within 30\u2009days. Costs for all patients enrolled were used. The sensitivity analysis utilizes EQ\u20105D\u20105L scores from the same population but only uses costs from this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>940 patients were randomized: 627 received CCP and 313 received standard care. The total costs were $28,716 (standard deviation, $25,380) and $24,258 ($22,939) for the convalescent plasma and standard care arms respectively. EQ\u20105D\u20105L scores were 0.61 in both arms (<jats:italic>p<\/jats:italic>\u2009=\u2009.85) at baseline. At 30\u2009days, EQ\u20105D\u20105L scores were 0.63 and 0.64 for patients in the convalescent plasma and standard care arms,\u00a0respectively (<jats:italic>p<\/jats:italic>\u2009=\u2009.46). The incremental cost was $4458 and the incremental quality\u2010adjusted life day was \u22120.078.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Convalescent plasma was less effective and more costly than standard care in treating hospitalized COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17777","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T12:44:38Z","timestamp":1711025078000},"page":"606-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quality of life and <scp>cost\u2010effectiveness<\/scp> of convalescent plasma compared to standard care for hospitalized <scp>COVID<\/scp>\u201019 patients in the <scp>CONCOR<\/scp>\u20101 trial"],"prefix":"10.1111","volume":"64","author":[{"given":"Preston","family":"Tse","sequence":"first","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Jamula","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9671-3501","authenticated-orcid":false,"given":"Nancy","family":"Heddle","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"},{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9594-2532","authenticated-orcid":false,"given":"Ren\u00e9e","family":"Bazin","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation, H\u00e9ma\u2010Qu\u00e9bec  Qu\u00e9bec City Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Robitaille","sequence":"additional","affiliation":[{"name":"H\u00e9ma\u2010Qu\u00e9bec  Montreal Qu\u00e9bec Canada"},{"name":"Division of Hematology\u2010Oncology, Department of Pediatrics CHU Sainte\u2010Justine  Montreal Qu\u00e9bec 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Research Institute  Ottawa Ontario Canada"},{"name":"Department of Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall","family":"Glesby","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent Cadogan","family":"Loftsgard","sequence":"additional","affiliation":[{"name":"UBC Health Team\u2010Based Care  Vancouver British Columbia USA"},{"name":"CIHR\u2010Strategy for Patient\u2010Oriented Research  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8042-1494","authenticated-orcid":false,"given":"Melissa","family":"Cushing","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Weill Cornell Medicine  New York New York 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