{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:19:47Z","timestamp":1788347987215,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Anaplasma phagocytophilum<\/jats:italic> is a tick\u2010borne bacterium and the cause of human granulocytic anaplasmosis (HGA). Here, we report a case of transfusion\u2010transmitted (TT)\u2010HGA involving a leukoreduced (LR) red blood cell (RBC) unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>A 64\u2010year\u2010old woman with gastric adenocarcinoma and multiple myeloma who received weekly blood transfusions developed persistent fevers, hypotension, and shortness of breath 1\u2009week after receiving an RBC transfusion. Persistent fevers, new thrombocytopenia, and transaminitis suggested a tick\u2010borne infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The absence of blood parasites on thick and thin blood smears suggested that malaria and <jats:italic>Babesia<\/jats:italic> infection were not present, and the recipient tested negative for antibodies to <jats:italic>Borrelia burgdorferi<\/jats:italic>. Blood testing by polymerase chain reaction (PCR) for <jats:italic>Ehrlichia<\/jats:italic> and <jats:italic>Anaplasma<\/jats:italic> species identified <jats:italic>A. phagocytophilum<\/jats:italic>. Treatment with doxycycline resolved the infection; however, the recipient expired due to complications of her known malignancies. The recipient lived in a nursing home and did not have pets or spend time outdoors. The donor was a female in her 70s from Maine who was diagnosed with HGA 3\u2009weeks after donating blood and whose LR\u2010RBCs from the donation were transfused to the recipient 9\u2009days following collection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is a confirmed case of TT\u2010HGA. Although rare, TT\u2010HGA has been reported with LR\u2010RBCs and platelets. In endemic areas, testing for tick\u2010borne associated infections should be considered when investigating post\u2010transfusion complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17783","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T11:59:30Z","timestamp":1710590370000},"page":"751-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A case of transfusion\u2010transmission <i>Anaplasma phagocytophilum<\/i> from leukoreduced red blood cells"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7735-8420","authenticated-orcid":false,"given":"Laura","family":"Tonnetti","sequence":"first","affiliation":[{"name":"Scientific Affairs, American Red Cross  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Marcos","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Stony Brook University Hospital  Stony Brook New York USA"},{"name":"Department of Microbiology and Immunology Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Mamone","sequence":"additional","affiliation":[{"name":"Department of Pathology Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8794-2441","authenticated-orcid":false,"given":"Eric D.","family":"Spitzer","sequence":"additional","affiliation":[{"name":"Department of Pathology Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Jacob","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Stony Brook University Hospital  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca 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