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Freeze\u2010dried plasma (FDP), which contains coagulation factors, is a promising adjunct in hemostatic resuscitation. We explore the association between FDP alone or in combination with other blood products on 24\u2010h mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>This is a secondary data analysis from a cross\u2010sectional prospective observational multicenter study of adult trauma patients in the Western Cape of South Africa. We compare mortality among trauma patients at risk of hemorrhage in three treatment groups: Blood Products only, FDP\u2009+\u2009Blood Products, and FDP only. We apply inverse probability of treatment weighting and fit a multivariable Cox proportional hazards model to assess the hazard of 24\u2010h mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and forty\u2010eight patients were included, and 55 (12.2%) died within 24 h of hospital arrival. Compared to the Blood Products only group, we found no difference in 24\u2010h mortality for the FDP\u2009+\u2009Blood Product group (<jats:italic>p<\/jats:italic>\u2009=\u2009.40) and a lower hazard of death for the FDP only group (hazard\u2009=\u20090.38; 95% CI, 0.15\u20131.00;<jats:italic>p<\/jats:italic>\u2009=\u2009.05). However, sensitivity analyses showed no difference in 24\u2010h mortality across treatments in subgroups with moderate and severe shock, early blood product administration, and accounting for immortal time bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found insufficient evidence to conclude there is a difference in relative 24\u2010h mortality among trauma patients at risk for hemorrhage who received FDP alone, blood products alone, or blood products with FDP. There may be an adjunctive role for FDP in hemorrhagic shock resuscitation in settings with significantly restricted access to blood products.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17792","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T13:14:47Z","timestamp":1710854087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of<scp>freeze\u2010dried<\/scp>plasma with<scp>24\u2010h<\/scp>mortality among trauma patients at risk for hemorrhage"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4303-6903","authenticated-orcid":false,"given":"Nee\u2010Kofi","family":"Mould\u2010Millman","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine University of Colorado School of Medicine, Anschutz Medical Campus Aurora Colorado 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