{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T03:07:06Z","timestamp":1776395226313,"version":"3.51.2"},"reference-count":38,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Low\u2010titer group O whole blood (LTOWB) for treatment of hemorrhagic shock sometimes necessitates transfusion of RhD\u2010positive units due to short supply of RhD\u2010negative LTOWB. Practitioners must choose between using RhD\u2010positive LTOWB when RhD\u2010negative is unavailable against the risk to a female of childbearing potential of becoming RhD\u2010alloimmunized, risking hemolytic disease of the fetus and newborn (HDFN) in future children, or using component therapy with RhD\u2010negative red cells. This survey asked females with a history of red blood cell (RBC) alloimmunization about their risk tolerance of RhD alloimmunization compared to the potential for improved survival following transfusion of RhD\u2010positive blood for an injured RhD negative female child.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>A survey was administered to RBC alloimmunized mothers. Respondents were eligible if they were living in the United States with at least one red cell antibody known to cause HDFN and if they had at least one RBC alloimmunized pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Responses from 107 RBC alloimmmunized females were analyzed. There were 32\/107 (30%) with a history of severe HDFN; 12\/107 (11%) had a history of fetal or neonatal loss due to HDFN. The median (interquartile range) absolute improvement in survival at which the respondents would accept RhD\u2010positive transfusions for a female child was 4% (1%\u201314%). This was not different between females with and without a history of severe or fatal HDFN (<jats:italic>p<\/jats:italic>\u2009=\u2009.08 and 0.38, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Alloimmunized mothers would accept the risk of D\u2010alloimmunization in a RhD\u2010negative female child for improved survival in cases of life\u2010threatening bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17807","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T15:30:10Z","timestamp":1712071810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Receipt of RhD\u2010positive whole blood for life\u2010threatening bleeding in female children: A survey in alloimmunized mothers regarding minimum acceptable survival benefit relative to risk of maternal alloimmunization to anti\u2010D"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6634-2193","authenticated-orcid":false,"given":"Molly R.","family":"Sherwood","sequence":"first","affiliation":[{"name":"Allo Hope Foundation  Tuscaloosa Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0037-8955","authenticated-orcid":false,"given":"Skye","family":"Clayton","sequence":"additional","affiliation":[{"name":"Trauma and Transfusion Medicine Research Center, Department of Surgery University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8561-8760","authenticated-orcid":false,"given":"Christine M.","family":"Leeper","sequence":"additional","affiliation":[{"name":"Trauma and Transfusion Medicine Research Center, Department of Surgery University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5937-3301","authenticated-orcid":false,"given":"Mark","family":"Yazer","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5028-8426","authenticated-orcid":false,"suffix":"Jr","given":"Kenneth J.","family":"Moise","sequence":"additional","affiliation":[{"name":"Department of Women's Health Dell Medical School\u2010UT Health  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0385-5776","authenticated-orcid":false,"given":"Marion E.","family":"Granger","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of South Carolina  Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-0541","authenticated-orcid":false,"given":"Philip C.","family":"Spinella","sequence":"additional","affiliation":[{"name":"Trauma and Transfusion Medicine Research Center, Department of Surgery University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005075"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.12"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001425"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15161"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000004103"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000004081"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2021.1967257"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000519676"},{"issue":"3","key":"e_1_2_7_10_1","first-page":"S2","article-title":"The use of low\u2010titer group O whole blood is independently associated with improved survival compared to 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Available from:https:\/\/allohopefoundation.org\/wp-content\/uploads\/2023\/11\/Final-listening-session-whitepaper.pdf"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.11.343"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-022-05329-z"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T11:23:10Z","timestamp":1715253790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.17807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,2]]},"references-count":38,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/trf.17807"],"URL":"https:\/\/doi.org\/10.1111\/trf.17807","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,2]]},"assertion":[{"value":"2023-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}