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Knowing that Human Platelet Antigens (HPA) are located on the platelet glycoproteins that can be absent in these patients, preventive HPA\u2010matching may also be considered. Uniform recommendations on this topic lack in transfusion guidelines making standard practice unclear, therefore, we aimed to provide a framework for matched platelet transfusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We conducted a targeted literature search and a national survey of Dutch (pediatric) hematologists from July to September 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found 20 articles describing platelet transfusion policies in 483 GT\u2010patients and 29 BSS\u2010patients, both adults and children. Twenty surveys were returned for full analysis. All responders treated patients with platelet disorders, including GT (<jats:italic>n<\/jats:italic>\u2009=\u200936 reported) and BSS (<jats:italic>n<\/jats:italic>\u2009=\u200929 reported). Of respondents, 75% estimated the risk of antibody formation as \u201clikely\u201d for HLA and 65% for HPA. Formation of HLA antibodies was reported in 5 GT and in 5 BSS\u2010patients, including one child. Fifteen respondents gave preventive HLA\u2010matched platelets in elective setting (75%). Three respondents additionally matched for HPA in GT\u2010patients (15%). Main argument for matched platelet transfusions was preventing alloimmunization to safeguard the effectivity of \u2018random\u2019 donor\u2010platelets in acute settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elective HLA\u2010matching for GT and BSS\u2010patients is already conducted by most Dutch (pediatric) hematologists. HPA\u2010matching is mainly applied when HPA\u2010antibodies are formed. Based on the current literature and the survey, recommendations are proposed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17824","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T12:35:28Z","timestamp":1713616528000},"page":"824-838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Should HLA and HPA\u2010matched platelet transfusions for patients with Glanzmann Thrombasthenia or Bernard\u2010Soulier syndrome be standardized care? 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Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schipperus","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjon H.","family":"Cnossen","sequence":"additional","affiliation":[{"name":"Department of Medical Affairs Unit of Transfusion Medicine, Sanquin Blood bank  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masja","family":"de Haas","sequence":"additional","affiliation":[{"name":"Department of Immunohematology Diagnostics Sanquin Diagnostic Services and Sanquin Research  Amsterdam The Netherlands"},{"name":"Department of Hematology Leiden University Medical Center  Leiden The 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