{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:44:31Z","timestamp":1783536271463,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite recent advances in the treatment of multiple myeloma, high\u2010dose chemotherapy followed by autologous hematopoietic stem cell transplantation (ASCT) remains an essential therapeutic keystone. As for the stem cell mobilization procedure, different regimens have been established, usually consisting of a cycle of chemotherapy followed by application of granulocyte\u2010colony stimulating factor (G\u2010CSF), although febrile neutropenia is a common complication. Following national guidelines, our institution decided to primarily use G\u2010CSF only mobilization during the COVID\u201019 pandemic to minimize the patients' risk of infection and to reduce the burden on the health system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>In this retrospective single\u2010center analysis, the efficacy and safety of G\u2010CSF only mobilization was evaluated and compared to a historic control cohort undergoing chemotherapy\u2010based mobilization by cyclophosphamide and etoposide (CE) plus G\u2010CSF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although G\u2010CSF only was associated with a higher need for plerixafor administration (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) and a higher number of apheresis sessions per patient (<jats:italic>p<\/jats:italic>\u2009=\u2009.0002), we were able to collect the target dose of hematopoietic stem cells in the majority of our patients. CE mobilization achieved higher hematopoietic stem cell yields (<jats:italic>p<\/jats:italic>\u2009=\u2009.0015) and shorter apheresis sessions (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) yet was accompanied by an increased risk of febrile neutropenia (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). There was no difference in engraftment after ASCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>G\u2010CSF only mobilization is a useful option in selected patients with comorbidities and an increased risk of serious infections, especially in the wintertime or in future pandemics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17829","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T05:14:28Z","timestamp":1712812468000},"page":"871-880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of two autologous hematopoietic stem cell mobilization strategies in patients with multiple myeloma: <scp>CE<\/scp> plus <scp>G\u2010CSF<\/scp> versus <scp>G\u2010CSF<\/scp> only: A single\u2010center retrospective analysis"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4258-4986","authenticated-orcid":false,"given":"Veronika","family":"Dill","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III Technical University of Munich, School of Medicine, Klinikum rechts der Isar  Munich Germany"},{"name":"German Cancer Consortium (DKTK), partner site Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Bl\u00fcm","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Technical University of Munich, School of Medicine, Klinikum rechts der Isar  Munich Germany"},{"name":"Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service Baden\u2010W\u00fcrttemberg\u2010Hessen  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Lindemann","sequence":"additional","affiliation":[{"name":"TUMCells Interdisciplinary Center for Cellular Therapies, Technical University of Munich, School of Medicine  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2805-8231","authenticated-orcid":false,"given":"Alexander","family":"Biederst\u00e4dt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Technical University of Munich, School of Medicine, Klinikum rechts der Isar  Munich Germany"},{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"H\u00f6gner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Technical University of Munich, School of Medicine, Klinikum rechts der Isar  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina S.","family":"G\u00f6tze","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Technical University of Munich, School of Medicine, Klinikum rechts der Isar  Munich Germany"},{"name":"German Cancer Consortium (DKTK), partner site Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Bassermann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Technical University of Munich, School of Medicine, Klinikum rechts der Isar  Munich Germany"},{"name":"German Cancer Consortium (DKTK), partner site Munich  Munich Germany"},{"name":"Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich  Munich Germany"},{"name":"Bavarian Cancer Research Center (BZKF)  Munich 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