{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:50:40Z","timestamp":1793746240148,"version":"4.6.1"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["#U01\u00a3 CK000570\u201004"],"award-info":[{"award-number":["#U01\u00a3 CK000570\u201004"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>For many years, there has been concern about the risk of transmission of classic forms of Creutzfeldt\u2010Jakob disease (CJD) by blood transfusion, particularly after the recognition of such transmission of variant CJD (vCJD). We report on a 28\u2010year lookback study of recipients of blood from donors who subsequently developed CJD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with diagnosed CJD and a history of blood donation were identified. Blood centers were asked to provide information about the distribution of the donations and consignees were requested to provide information about the recipients of the donations. Vital status of each available recipient was determined and, if deceased, the reported cause(s) of death were obtained primarily from the National Death Index. All recipients included in the study database contributed person\u2010time up to the last recorded review of vital status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 84 eligible donors who gave 3284 transfusable components, and it was possible to evaluate 1245 recipients, totaling 6495 person\u2010years of observation. The mean observation period per recipient was 5.5\u2009years with a maximum of 51\u2009years. No case of CJD or prion disease was reported among the recipient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The study suggests that CJD may not be transfusion\u2010transmissible, a position in agreement with similar findings from two similar European reports amounting to an overall observation period of 15,500 person\u2010years. These studies have supported the conclusion that the risk, if any, of transmission of CJD by blood products is extremely small and remains theoretical.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17837","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T05:59:39Z","timestamp":1713851979000},"page":"980-985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Absence of evidence of transfusion transmission risk of Creutzfeldt\u2010Jakob disease in the United States: Results froma 28\u2010year lookback study"],"prefix":"10.1111","volume":"64","author":[{"given":"Lauren A.","family":"Crowder","sequence":"first","affiliation":[{"name":"American Red Cross, Medical &amp; Scientific Office  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger Y.","family":"Dodd","sequence":"additional","affiliation":[{"name":"American Red Cross, Medical &amp; Scientific Office  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence B.","family":"Schonberger","sequence":"additional","affiliation":[{"name":"Division of High\u2010Consequence Pathogens and Pathology US Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2006.00833.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16811-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12371"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15751"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12631"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15763"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-20565-1_12"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2306.161884"},{"key":"e_1_2_9_10_1","volume-title":"Guidance for industry: recommendations to reduce the possible risk of transmission of Creutzfeldt\u2010Jakob disease and variant Creutzfeldt\u2010Jakob disease by blood and blood components","author":"Food and Drug Administration","year":"2022"},{"key":"e_1_2_9_11_1","first-page":"665","article-title":"Surveillance for Creutzfeldt\u2010Jakob disease\u2014United States","volume":"45","author":"Centers for Disease Control and Prevention","year":"1996","journal-title":"Morb Mortal Wkly Rep"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109771"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2014.02.002"},{"key":"e_1_2_9_14_1","first-page":"629","volume-title":"Prion biology and diseases","author":"Will RG","year":"2004"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T10:00:51Z","timestamp":1728986451000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.17837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/trf.17837"],"URL":"https:\/\/doi.org\/10.1111\/trf.17837","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,22]]},"assertion":[{"value":"2024-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}