{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T04:13:12Z","timestamp":1749528792354,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited studies have explored the association between clinical symptoms and titers of SARS\u2010CoV\u20102 antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>In this cross\u2010sectional study, whole\u2010blood donors who had experienced a confirmed or suspected COVID\u201019 infection completed questionnaires at the time of blood donation. Plasma SARS\u2010CoV\u20102 immunoglobulin G (IgG) titers were measured using an enzyme\u2010linked immunosorbent assay. Logistic regression models were used to calculate odds ratios (ORs) for high\u2010titer COVID\u201019 convalescent plasma (CCP) for each variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the total 386 donors, 120 (31%) donors with IgG titers \u22651:160 were classified as high\u2010titer donors. The multivariable ORs (95% confidence intervals [CIs]) for high titers were 2.33 (1.45\u20133.75), 2.11 (1.29\u20133.43), 1.10 (1.01\u20131.21), 1.19 (1.00\u20131.43), and 1.97 (1.05\u20133.71) for sore throat, cough, symptom count, fever duration, and low fever (compared with non\u2010fever), respectively. No significant association was observed between other symptoms and medical visits and the odds of high\u2010titer CCP. The association between high\u2010titer CCP and fever duration was restricted to confirmed COVID\u201019\u2010infected donors, while associations with sore throat and cough remained significant in suspected infected donors. In addition, medical visit was positively associated with high\u2010titer CCP in suspected donors, but not in confirmed donors. In bootstrapped logistic regression models, the associations remained significant and reproducible for medical visit in suspected donors and for sore throat and cough in both suspected donors and total donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Experiencing a sore throat and cough were associated with high\u2010titer CCP in overall donors. We also identified sore throat, cough, and medical visits as potential predictors of high\u2010titer CCP for suspected donors during the pandemic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17843","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T12:03:47Z","timestamp":1714046627000},"page":"1025-1039","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between clinical symptoms during the <scp>COVID<\/scp>\u201019 infection and <scp>SARS\u2010CoV<\/scp>\u20102 immunoglobulin <scp>G<\/scp> titers in <scp>COVID<\/scp>\u201019 convalescent whole\u2010blood donors in China"],"prefix":"10.1111","volume":"64","author":[{"given":"Xue","family":"Chen","sequence":"first","affiliation":[{"name":"Blood Research Laboratory Chengdu Blood Center  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Blood Testing Chengdu Blood Center  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[{"name":"Blood Research Laboratory Chengdu Blood Center  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxun","family":"Kang","sequence":"additional","affiliation":[{"name":"Blood Research Laboratory Chengdu Blood Center  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Blood Testing Chengdu Blood Center  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Luo","sequence":"additional","affiliation":[{"name":"Blood Research Laboratory Chengdu Blood Center  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinman","family":"Du","sequence":"additional","affiliation":[{"name":"Blood Research Laboratory Chengdu Blood Center  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donglin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Blood Processing Chengdu Blood Center  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Blood Collection Chengdu Blood Center  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Blood Collection Chengdu Blood Center  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zonghan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Blood Collection Chengdu Blood Center  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3371-6171","authenticated-orcid":false,"given":"Xuemei","family":"Fu","sequence":"additional","affiliation":[{"name":"Blood Research Laboratory Chengdu Blood Center  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6102-9451","authenticated-orcid":false,"given":"Jingyun","family":"Tang","sequence":"additional","affiliation":[{"name":"Blood Research Laboratory Chengdu Blood Center  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Further Implementation of COVID\u201019 Prevention and Control Measures [cited 2023 Aug 8]. 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