{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:42:34Z","timestamp":1791776554661,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A 54\u2010year\u2010old Hispanic OPos female with known history of anti\u2010Rh17 antibodies was diagnosed with Philadelphia\u2010Chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). Rh17, also known as Hr<jats:sub>0<\/jats:sub>, is a high\u2010frequency antigen composed of several epitopes on the RhCE protein. Anti\u2010Rh17 antibodies can be made by individuals with missing or varied C\/c, E\/e antigens. Anti\u2010Rh17 antibodies are clinically significant given multiple case reports of hemolytic disease of the fetus and newborn (HDFN). Finding compatible units for patients with anti\u2010Rh17 can be particularly difficult given that only 1 in 100,000 people are Rh17 negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Search for compatible units was conducted by the American Rare Donor Program (ARDP) with no leads. After chemotherapy induction and despite erythropoiesis stimulating agent administration, the patient's hemoglobin continued to trend down to a nadir of 2.8\u2009g\/dL. Here we report transfusion of incompatible pRBC to this patient with critically symptomatic anemia. HBOC\u2010201 (Hemopure) was obtained and administered under an emergency compassionate\/expanded access designation from the Food and Drug Administration (FDA) under an emergency Investigational New Drug (IND) application.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Discussion<\/jats:title><jats:p>Overall difficulties in this case included the challenge of finding compatible units, dilemma of transfusing incompatible units in a patient with severe anemia and obtaining alternatives to blood products. This case report demonstrates the successful use of HBOC\u201021 in treating life\u2010threatening anemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17855","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T13:03:31Z","timestamp":1714395811000},"page":"1161-1166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Transfusion management and hemoglobin\u2010based oxygen carrier treatment in a patient with <scp>anti\u2010Rh17<\/scp> antibody"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5297-402X","authenticated-orcid":false,"given":"Noah","family":"Mehr","sequence":"first","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Fuja","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Carll","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahaf","family":"Alkhateb","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulin","family":"Wu","sequence":"additional","affiliation":[{"name":"Section of Hematology\/Oncology, Department of Medicine University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0296-8686","authenticated-orcid":false,"given":"Anand A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Section of Hematology\/Oncology, Department of Medicine University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8295-1405","authenticated-orcid":false,"given":"Fatima","family":"Aldarweesh","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"337","volume-title":"The technical manual","author":"Vege S","year":"2023"},{"issue":"4","key":"e_1_2_8_3_1","first-page":"825","article-title":"Genetic recombination at the human RH locus: a family study of the red\u2010cell Evans phenotype reveals a transfer of exons 2\u20106 from the RHD to the RHCE gene","volume":"59","author":"Huang CH","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-415849-8.00006-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2020.102913"},{"key":"e_1_2_8_6_1","first-page":"182","volume-title":"Human blood groups","author":"Daniels G","year":"2005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000503012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000075147"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15778"},{"key":"e_1_2_8_10_1","unstructured":"Expanded Access Protocol for the Treatment Use of HBOC\u2010201.2021. 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