{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T11:45:44Z","timestamp":1748259944901,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT) results from maternal platelet alloimmunization against paternal antigens inherited by the fetus, most often due to the Human Platelet Antigen (HPA)\u20101 system in Caucasians. We investigated in 2023, a 30\u2010year\u2010old Caucasian woman Gravida 2 Para 1 who gave birth at 35\u2009weeks of gestation to a male (body weight 2210\u2009g) without signs of bleeding. A severe thrombocytopenia (platelet count at 3\u2009G\/L) was discovered incidentally a few hours after delivery in the context of the management of a respiratory distress. The newborn recovered after one platelet concentrate transfusion and normalized his platelet count at Day 5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>FNAIT investigation was performed according to guideline recommendations. Platelet genotyping was carried out by multiplex PCR. Maternal serological investigation included Monoclonal Antibody\u2010specific Immobilization of Platelet Antigens method (MAIPA) and Luminex technology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Parental and newborn genotyping pointed out an HPA\u20104 incompatibility between the mother and the newborn and the father. Serological investigation revealed an anti\u2010HPA\u20104b alloantibody confirming the diagnosis of neonatal alloimmune thrombocytopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We described the third case of anti\u2010HPA\u20104b alloantibody discovered in a Caucasian mother. This case strengthens the need for reference laboratory to genotype a panel of HPA alleles reflecting local genetic population diversity and for crossmatch of maternal serum with fresh paternal platelets in clinical suspected cases of neonatal alloimmune thrombocytopenia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17863","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T02:59:40Z","timestamp":1714618780000},"page":"1167-1170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Severe neonatal thrombocytopenia due to <scp>anti\u2010HPA<\/scp>\u20104b alloantibodies: Third report described in a Caucasian mother"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-6278","authenticated-orcid":false,"given":"Rachel","family":"Petermann","sequence":"first","affiliation":[{"name":"Hospital Saint\u2010Antoine, National Reference Center for Perinatal Hemobiology  Paris France"},{"name":"INSERM, UMR_S1134  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Hospital Saint\u2010Antoine, National Reference Center for Perinatal Hemobiology  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loubna","family":"Saib","sequence":"additional","affiliation":[{"name":"Hospital Saint\u2010Antoine, National Reference Center for Perinatal Hemobiology  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Ferr\u00e9","sequence":"additional","affiliation":[{"name":"Hospital Saint\u2010Antoine, National Reference Center for Perinatal Hemobiology  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Francelle","sequence":"additional","affiliation":[{"name":"Hospital Saint\u2010Antoine, National Reference Center for Perinatal Hemobiology  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Oudin","sequence":"additional","affiliation":[{"name":"Hospital Saint\u2010Antoine, National Reference Center for Perinatal Hemobiology  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Chenet","sequence":"additional","affiliation":[{"name":"Hospital Saint\u2010Antoine, National Reference Center for Perinatal Hemobiology  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmine","family":"Mammasse","sequence":"additional","affiliation":[{"name":"Hospital Saint\u2010Antoine, National Reference Center for Perinatal Hemobiology  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Jallu","sequence":"additional","affiliation":[{"name":"Hospital Saint\u2010Antoine, National Reference Center for Perinatal Hemobiology  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e9lie","family":"Chaussade","sequence":"additional","affiliation":[{"name":"Hopital Armand\u2010Trousseau, National Reference Center for Perinatal Hemobiology  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonin","family":"Cornu","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Rives de Seine Service de Neonatologie  Neuilly\u2010sur\u2010Seine France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laureline","family":"Dubray","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Rives de Seine Service de Neonatologie  Neuilly\u2010sur\u2010Seine France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Mailloux","sequence":"additional","affiliation":[{"name":"Hospital Saint\u2010Antoine, National Reference Center for Perinatal Hemobiology  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Versiti [En ligne].Versiti\u2014Human Platelet Antigen (HPA) Database. 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