{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:37:32Z","timestamp":1784875052900,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD102535"],"award-info":[{"award-number":["R01HD102535"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","award":["75F40120C00101"],"award-info":[{"award-number":["75F40120C00101"]}],"id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In May 2023, the Food and Drug Administration (FDA) released final guidance for blood donor eligibility that recommended the elimination of 3\u2010month deferral for men who have sex with men (MSM) and the related deferral for women who have sex with MSM. In its place, FDA introduced an individual risk assessment policy of asking all presenting blood donors, regardless of sex or gender, if they have had a new partner or more than one sexual partner in the last 3 months and deferring those who also report anal sex (penile\u2013anal intercourse) during this period. We modeled the possible impact of this policy on the US blood donor base.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We developed a computational model to estimate the percentage of blood donors who would be deferred under a policy of individual HIV risk assessment.<\/jats:p><jats:p>The model incorporated demographic information about donors and national survey data on HIV risk behaviors and included age and sex distributions and dependencies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our model estimates that approximately 1.2% of US blood donors would be deferred under the individual HIV risk assessment paradigm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The model predicts a relatively minor effect of replacing the time\u2010based deferral for MSM with individual risk\u2010based deferral for sexual behavior. As US blood centers implement this new policy, the effect may be mitigated by donor gains, which warrant further study. The new policy is unlikely to adversely affect the availability of blood and blood components.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17916","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T09:33:32Z","timestamp":1718184812000},"page":"1459-1468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modeling US blood donor deferrals under a policy of individual risk assessment for <scp>HIV<\/scp> risk sexual behavior"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6311-6268","authenticated-orcid":false,"given":"Barbee I.","family":"Whitaker","sequence":"first","affiliation":[{"name":"FDA Center for Biologics Evaluation and Research, Office of Biostatistics and Pharmacovigilance  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7333-2784","authenticated-orcid":false,"given":"Yin","family":"Huang","sequence":"additional","affiliation":[{"name":"FDA Center for Biologics Evaluation and Research, Office of Biostatistics and Pharmacovigilance  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Gubernot","sequence":"additional","affiliation":[{"name":"FDA Center for Biologics Evaluation and Research, Office of Biostatistics and Pharmacovigilance  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-626X","authenticated-orcid":false,"given":"Anne F.","family":"Eder","sequence":"additional","affiliation":[{"name":"FDA Center for Biologics Evaluation and Research, Office of Blood Research and Review  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debby","family":"Herbenick","sequence":"additional","affiliation":[{"name":"Center for Sexual Health Promotion Indiana University  Bloomington Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010chieh","family":"Fu","sequence":"additional","affiliation":[{"name":"Center for Sexual Health Promotion Indiana University  Bloomington Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Forshee","sequence":"additional","affiliation":[{"name":"FDA Center for Biologics Evaluation and Research, Office of Biostatistics and Pharmacovigilance  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Anderson","sequence":"additional","affiliation":[{"name":"FDA Center for Biologics Evaluation and Research, Office of Biostatistics and Pharmacovigilance  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"HIV and the blood supply: an analysis of crisis Decisionmaking","author":"Institute of Medicine Committee to Study HIV Transmission Through Blood","year":"1995"},{"key":"e_1_2_9_3_1","first-page":"137","article-title":"Human immunodeficiency virus infection in transfusion recipients and their family members","volume":"36","author":"CDC","year":"1987","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_9_4_1","first-page":"652","article-title":"Possible transfusion\u2010associated acquired immune deficiency syndrome (AIDS)\u2014California","volume":"31","author":"CDC","year":"1982","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_9_5_1","first-page":"547","article-title":"Update: revised public health service definition of persons who should refrain from donating blood and plasma\u2013United 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