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This period might be insufficient for restoring hemoglobin mass (Hbmass) and iron especially in women, who generally have lower Hbmass and iron availability. Since both variables influence physical performance, this pilot study aimed to monitor Hbmass, iron status, and maximum oxygen uptake (V\u0307O<jats:sub>2max<\/jats:sub>) recovery in women after a single BD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>In 10 women (24.7\u2009\u00b1\u20091.7\u2009years), Hbmass, hemoglobin concentration [Hb], iron status, and V\u0307O<jats:sub>2max<\/jats:sub> were assessed before and up to 12\u2009weeks after a single BD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BD reduced Hbmass from 562\u2009\u00b1\u200970\u2009g to 499\u2009\u00b1\u200964\u2009g (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Although after 8\u2009weeks no significant mean difference was detected, 7 women had not returned to baseline after 12\u2009weeks. [Hb] did not return to initial values (13.4\u2009\u00b1\u20090.7\u2009g\/dL) after 12\u2009weeks (12.9\u2009\u00b1\u20090.7\u2009g\/dL, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Ferritin decreased from baseline until week 6 (40.9\u2009\u00b1\u200934.2\u2009ng\/mL vs. 12.1\u2009\u00b1\u20096.9\u2009ng\/mL, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) and was not restored after 12\u2009weeks (18.4\u2009\u00b1\u200912.7\u2009ng\/mL, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), with 6 out of 10 women exhibiting iron deficiency (ferritin &lt;15\u2009ng\/mL). V\u0307O<jats:sub>2max<\/jats:sub> was reduced by 213\u2009\u00b1\u200947\u2009mL\/min (7.2\u2009\u00b1\u20091.2%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and remained below baseline after 12\u2009weeks (3.2\u2009\u00b1\u20091.4%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>For most pre\u2010menopausal women, 12\u2009weeks were not sufficient to recover from BD and achieve baseline Hbmass and iron stores resulting in prolonged reduction of aerobic capacity. A subsequent BD might lead to a severe anemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17917","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T11:59:01Z","timestamp":1718625541000},"page":"1481-1491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of a single blood donation on hemoglobin mass, iron stores, and maximum oxygen uptake in pre\u2010menopausal women\u2014A pilot study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6321-3594","authenticated-orcid":false,"given":"Nadine B.","family":"Wachsmuth","sequence":"first","affiliation":[{"name":"Division of Sports Medicine\/Sports Physiology University of Bayreuth  Bayreuth Germany"},{"name":"Division of Exercise Physiology and Metabolism, Bayreuth Center of Sport Science University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Haupt","sequence":"additional","affiliation":[{"name":"Division of Sports Medicine\/Sports Physiology University of Bayreuth  Bayreuth Germany"},{"name":"Division of Exercise Physiology and Metabolism, Bayreuth Center of Sport Science University of Bayreuth  Bayreuth Germany"},{"name":"Division of Molecular Exercise Physiology University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Bauer","sequence":"additional","affiliation":[{"name":"Division of Sports Medicine\/Sports Physiology University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis R.","family":"Schierbauer","sequence":"additional","affiliation":[{"name":"Division of Sports Medicine\/Sports Physiology University of Bayreuth  Bayreuth Germany"},{"name":"Division of Exercise Physiology and Metabolism, Bayreuth Center of Sport Science University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Treff","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Sports and Rehabilitation Medicine Ulm University  Ulm Germany"},{"name":"Institute of Molecular Sports Medicine and Rehabilitation Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen M.","family":"Steinacker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Sports and Rehabilitation Medicine Ulm University  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian","family":"Rilstone","sequence":"additional","affiliation":[{"name":"Department of Nutrition &amp; Dietetics, Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter F. 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