{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:15:31Z","timestamp":1788992131714,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012023","name":"Stichting Sanquin Bloedvoorziening","doi-asserted-by":"publisher","award":["PPOC 20\u201010"],"award-info":[{"award-number":["PPOC 20\u201010"]}],"id":[{"id":"10.13039\/501100012023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Less discriminatory donor selection policies for men who have sex with men (MSM) may impact transfusion safety in terms of higher residual risks for known transfusion\u2010transmitted infections (TTIs), increased vulnerability toward new TTIs that are also transmitted via sex, and HIV infections masked by pre\u2010exposure prophylaxis (PrEP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>TTI trends in Dutch donors were studied over a 13\u2010year period (2011\u20132023), characterized by successive relaxations of MSM deferral criteria. Structured posttest counseling was performed to determine risk factors in TTI\u2010positive donors. PrEP drug levels were measured in 9977 donations from male donors living in urban areas and in 67 donors with active or resolved syphilis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HIV incidence (from 5.8 to 1.5 per 1,000,000 donor years (DY)) and HBV incidence (from 12.4 to 4.5 per 1,000,000 DY) in Dutch donors decreased with less stringent MSM deferral criteria, while syphilis prevalence (from 26.4 to 44.1 per 100,000 new donors) and syphilis incidence (from 18.3 to 46.3 per 1,000,000 DY) increased over time. The proportion of MSM\u2010related syphilis rose from 2% to 32% in new donors and from 12% to 27% in repeat donors. PrEP was detected in 2 of 9977 (0.02%) donations from male donors living in urban areas, and in 1 of 39 (2.6%) male donors with syphilis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>To date, phasing out donor deferral for MSM had no significant impact on transfusion safety in the Netherlands. However, rising syphilis rates and (recent) PrEP use in the blood donor population, albeit rare, suggest an influx of donors with higher sexual risk profiles and requires intensified TTI surveillance in donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17941","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T14:33:39Z","timestamp":1720103619000},"page":"1732-1742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Blood safety markers in Dutch donors after relaxation of deferral for men who have sex with men: re\u2010emergence of syphilis and <scp>HIV<\/scp> pre\u2010exposure prophylaxis use"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-9254","authenticated-orcid":false,"given":"Franke A.","family":"Quee","sequence":"first","affiliation":[{"name":"Department of Donor Medicine Research Sanquin Research  Amsterdam The Netherlands"},{"name":"Department of Public and Occupational Health Amsterdam UMC  Amsterdam The Netherlands"},{"name":"Amsterdam Public Health (APH) Research Institute Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Slot","sequence":"additional","affiliation":[{"name":"Department of Medical Affairs Sanquin Corporate Staff  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Onze Lieve Vrouwe Gasthuis  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Brands","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Onze Lieve Vrouwe Gasthuis  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J. F.","family":"Franssen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Onze Lieve Vrouwe Gasthuis  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris M.","family":"Hogema","sequence":"additional","affiliation":[{"name":"Department of Donor Medicine Research Sanquin Research  Amsterdam The Netherlands"},{"name":"Department of Virology Sanquin Diagnostic Services  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0773-7315","authenticated-orcid":false,"given":"Hans L.","family":"Zaaijer","sequence":"additional","affiliation":[{"name":"Department of Donor Medicine Research Sanquin Research  Amsterdam The Netherlands"},{"name":"Department of Virology Sanquin Diagnostic Services  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6934-5056","authenticated-orcid":false,"given":"Thijs J. W.","family":"van de Laar","sequence":"additional","affiliation":[{"name":"Department of Donor Medicine Research Sanquin Research  Amsterdam The Netherlands"},{"name":"Department of Virology Sanquin Diagnostic Services  Amsterdam The Netherlands"},{"name":"Department of Medical Microbiology Onze Lieve Vrouwe Gasthuis  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13298"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12623"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-833996"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2674"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bioe.13063"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16896"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13587"},{"key":"e_1_2_8_9_1","unstructured":"SHM Monitoring Report 2023. 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