{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:36:43Z","timestamp":1774330603766,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hemorrhagic shock is well documented as a leading cause of preventable fatalities among military casualties. During military operations plasma can be transfused while waiting for whole blood. This study was conducted to assess the safety and efficacy of two new freeze\u2010dried plasma formulations in a porcine model of traumatic hemorrhagic shock.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>In the face of species\u2010specific transfusion, transfusible blood products were derived from porcine sources. The efficacy of three lyophilized plasma (LP) formulations was evaluated: lyophilized plasma (LP), concentrated lyophilized plasma (CLP), and platelet\u2010rich concentrated lyophilized plasma (PCLP). Pigs were subjected to multi\u2010trauma and hemorrhagic shock. Ninety minutes post\u2010shock induction, the animals were treated with one of the three lyophilized products. Monitoring included systolic blood pressure and cardiac output. Point\u2010of\u2010care and laboratory diagnostic tests were used to assess renal function, real\u2010time hemostasis (ROTEM), and coagulation. Histological examinations of kidney, lung, and muscle tissues were conducted 4\u2009h after shock induction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CLP and PCLP significantly improved systolic blood pressure and cardiac output and positively influenced base excess, creatinine, various ROTEM, and coagulation markers compared with standard LP without histologic modification. No adverse effect was associated with the transfusion of any of the plasma products throughout the experimental procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both CLP and PCLP exhibit promising therapeutic potential for managing hemorrhagic shock in scenario where whole blood supplies are limited. However, the distinct physiological and coagulation characteristics of the swine model necessitate further investigation using humanized preclinical models to fully understand their clinical applicability and constraints.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17971","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T20:00:47Z","timestamp":1723233647000},"page":"1670-1682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and safety of novel freeze\u2010dried plasma products in a porcine combat casualty model"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0632-0247","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9rique","family":"Dufour\u2010Gaume","sequence":"first","affiliation":[{"name":"Unit\u00e9 Traumatologie de Guerre, Institut de Recherche Biom\u00e9dicale Des Arm\u00e9es  Br\u00e9tigny Sur Orge France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9n\u00e9tia","family":"Cardona","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Traumatologie de Guerre, Institut de Recherche Biom\u00e9dicale Des Arm\u00e9es  Br\u00e9tigny Sur Orge France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Bordone","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Traumatologie de Guerre, Institut de Recherche Biom\u00e9dicale Des Arm\u00e9es  Br\u00e9tigny Sur Orge France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4905-9962","authenticated-orcid":false,"given":"Florent","family":"Montespan","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Traumatologie de Guerre, Institut de Recherche Biom\u00e9dicale Des Arm\u00e9es  Br\u00e9tigny Sur Orge France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Vest","sequence":"additional","affiliation":[{"name":"H\u00f4pital D'instruction Des Arm\u00e9es Percy  Clamart France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5852-9829","authenticated-orcid":false,"given":"Anne\u2010Margaux","family":"Legland","sequence":"additional","affiliation":[{"name":"H\u00f4pital D'instruction Des Arm\u00e9es Percy  Clamart France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadira","family":"Frescaline","sequence":"additional","affiliation":[{"name":"Service Innovation, Recherche et D\u00e9veloppement, Centre de Transfusion Sanguine des Arm\u00e9es  Clamart France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Prat","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Traumatologie de Guerre, Institut de Recherche Biom\u00e9dicale Des Arm\u00e9es  Br\u00e9tigny Sur Orge France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318221147b"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2016.10.043"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2017.11.029"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181271ba3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-016-0203-y"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318185a9ad"},{"key":"e_1_2_10_8_1","unstructured":"D\u00e9cision du 8 f\u00e9vrier 2018 fixant la liste et les caract\u00e9ristiques des produits sanguins labiles. 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