{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:45:41Z","timestamp":1769924741845,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Balanced plasma\/red blood cell transfusions have shown survival benefit in emergency scenarios. To improve plasma availability, we implemented 5\u2010day group A thawed plasma at our pediatric hospital in February 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We maintain thawed group A plasma units (5\u2010day shelf\u2010life) ready for immediate issue in the blood bank (since February 2021) and trauma code room (since August 2022). Group A plasma (un\u2010titered) is issued for patients with unknown blood type during emergencies. We retrospectively reviewed records and laboratory results of recipients to assess safety and identify possible adverse events related to incompatible plasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between February 2021 and December 2023, 173 emergency plasma requests occurred for 161 patients. Ninety\u2010one occurred with massive transfusion protocol activations. Thirty\u2010six patients (22.4%) were blood group B or AB, and 23 received incompatible plasma (age 0\u201321.3\u2009years, weight 0.74\u2013149.8\u2009kg, incompatible plasma dose 4.0\u2013428.4\u2009mL\/kg). These patients did not have any differences in survival outcomes or hospital lengths of stay (LOS) compared with compatible plasma recipients, mirroring the adult experience. None experienced adverse events related to group A plasma. No transfusion reactions were reported. No increase in wastage\/outdate occurred upon thawed plasma implementation (2020 versus 2021 to 2023, 7.73% [133\/1721] vs. 8.58% [497\/5792], <jats:italic>p<\/jats:italic>\u2009=\u2009.284).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We implemented 5\u2010day group A thawed plasma. Units are rapidly available from the blood bank and trauma code room without increased wastage. We did not identify any transfusion\u2010associated adverse events in pediatric recipients of incompatible group A plasma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.17985","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T06:58:01Z","timestamp":1723618681000},"page":"1851-1859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Use of group A thawed plasma in emergency transfusions at a pediatric quaternary care center"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1281-0644","authenticated-orcid":false,"given":"Cyril","family":"Jacquot","sequence":"first","affiliation":[{"name":"Division of Laboratory Medicine Children's National Hospital  Washington DC USA"},{"name":"Departments of Pathology and Pediatrics George Washington University School of Medicine and Health Sciences  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahirah","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine Children's National Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burak","family":"Bahar","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine Children's National Hospital  Washington DC USA"},{"name":"Departments of Pathology and Pediatrics George Washington University School of Medicine and Health Sciences  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Cabacar","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine Children's National Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1463-4963","authenticated-orcid":false,"given":"Jennifer","family":"Webb","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Pediatrics George Washington University School of Medicine and Health Sciences  Washington DC USA"},{"name":"Division of Hematology Children's National Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunchuan Delores","family":"Mo","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine Children's National Hospital  Washington DC USA"},{"name":"Departments of Pathology and Pediatrics George Washington University School of Medicine and Health Sciences  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Tavares da Souza","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine Children's National Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1089-5787","authenticated-orcid":false,"given":"Meghan","family":"Delaney","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine Children's National Hospital  Washington DC USA"},{"name":"Departments of Pathology and Pediatrics George Washington University School of Medicine and Health Sciences  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1804754"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005075"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002907"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.07.041"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02198.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13527"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14139"},{"issue":"1","key":"e_1_2_8_9_1","first-page":"S8","article-title":"Safety profile of low\u2010titer group O whole blood in pediatric patients with massive hemorrhage","volume":"61","author":"Morgan KM","year":"2021","journal-title":"Transfusion"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12372"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.14423\/SMJ.0000000000000686"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.17985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T04:32:43Z","timestamp":1729485163000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.17985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,13]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/trf.17985"],"URL":"https:\/\/doi.org\/10.1111\/trf.17985","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,13]]},"assertion":[{"value":"2024-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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