{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:03Z","timestamp":1787016063840,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite several reports on red blood cell (RBC) alloimmunization, the actual prevalence and factors contributing to RBC alloimmunization in transfused patients remain poorly investigated. We examined the association between clinical factors and the development and evanescence of RBC antibodies after transfusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>Each participating institution performed antibody screens before and after RBC transfusion. A survey including patient characteristics, results of antibody screen and identification, antibody screen methods, total amount of RBC transfused, and adverse reactions, was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between October 2018 and March 2023, 1194 patients were registered at five institutions. Overall, 958 patients underwent at least one follow\u2010up RBC antibody screen after transfusion, revealing new antibody development in 44 (4.6%). Anti\u2010E was identified in 25 patients, anti\u2010Jk\n                      <jats:sup>a<\/jats:sup>\n                      in 5, and anti\u2010c in 4. The number of RBC units transfused was significantly associated with antibody development after transfusion (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Among 55 patients in whom antibodies were identified after transfusion, including historical antibodies, antibodies evanesced in 18 (33%); anti\u2010E in 7, anti\u2010Jk\n                      <jats:sup>a<\/jats:sup>\n                      in 4, and anti\u2010Le\n                      <jats:sup>a<\/jats:sup>\n                      in 2. Evanescent antibodies were identified more frequently by saline and\/or enzyme methods than persistent antibodies (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.012).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The number of RBC units transfused can impact antibody development, and antibodies identified only by saline and\/or enzyme methods, deemed clinically insignificant, are likely to have a high evanescence rate. Antibody screen should be carefully performed, especially in those receiving a large number of RBC units. Confirming previous antibody screen results should be performed to prevent omitting evanesced antibodies regardless of clinical relevance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.18009","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T12:14:14Z","timestamp":1726575254000},"page":"1980-1992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The development and evanescence of red blood cell antibodies after transfusion:\n                    <scp>A<\/scp>\n                    multi\u2010institutional prospective study in\n                    <scp>Japan<\/scp>"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2465-2949","authenticated-orcid":false,"given":"Chiaki","family":"Yamada","sequence":"first","affiliation":[{"name":"Transfusion and Cell Therapy Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Ono","sequence":"additional","affiliation":[{"name":"Transfusion and Cell Therapy Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaede","family":"Ino","sequence":"additional","affiliation":[{"name":"Transfusion and Cell Therapy Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Transfusion and Cell Therapy Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Shinba","sequence":"additional","affiliation":[{"name":"Transfusion and Cell Therapy Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5202-1522","authenticated-orcid":false,"given":"Hiroaki","family":"Furumaki","sequence":"additional","affiliation":[{"name":"Transfusion and Cell Therapy Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Shibata","sequence":"additional","affiliation":[{"name":"Transfusion and Cell Therapy Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Ishizuka","sequence":"additional","affiliation":[{"name":"Transfusion and Cell Therapy Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naotomo","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6307-3379","authenticated-orcid":false,"given":"Hideaki","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Fujita Health University  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Izuhara","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Osaka Medical and Pharmaceutical University  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harumi","family":"Fujihara","sequence":"additional","affiliation":[{"name":"Transfusion Medicine &amp; Cell Therapy Kochi University  Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Minamiguchi","sequence":"additional","affiliation":[{"name":"Blood Transfusion and Cell Therapy Center Shiga University of Medical Science  Otsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2012.07.020"},{"key":"e_1_2_8_3_1","unstructured":"Fatalities reported to FDA following blood collection and transfusion annual summary for FY 2021. Available from:https:\/\/www.fda.gov\/media\/172382\/download"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17529"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12643"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12511"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13867"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12222"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12970"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13296"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24051"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2009.01241.x"},{"key":"e_1_2_8_13_1","volume-title":"Technical manual","author":"Claudia SC","year":"2023"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20120051"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.02014.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14157"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.14423\/SMJ.0000000000000528"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-08-833962"},{"issue":"3","key":"e_1_2_8_19_1","first-page":"311","article-title":"Increased detection of clinically significant antibodies and decreased incidence of delayed haemolytic transfusion reaction with the indirect antiglobulin test potentiated by polyethylene glycol compared to albumin: a Japanese study","volume":"9","author":"Okutsu M","year":"2011","journal-title":"Blood Transfus"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2020.09.001"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3925\/jjtc.65.810"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2020.102944"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2017.05.006"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00708.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/532919"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40091127.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2011.01073.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.5348\/100053Z02MW2020RA"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-227793"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13123"},{"key":"e_1_2_8_32_1","unstructured":"Annual SHOT Report;2022. Available from:https:\/\/www.shotuk.org\/wp-content\/uploads\/myimages\/SHOT-REPORT-2022-FINAL-Bookmarked.pdf"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14609"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2011.01517.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15004"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2016.1.446"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12430"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14538"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15718"},{"issue":"1","key":"e_1_2_8_40_1","first-page":"129","article-title":"Maternal cold\u2010reacting immunoglobulin G anti\u2010M of MNS blood group system causing hemolytic disease of the fetus","volume":"20","author":"Liang YL","year":"2023","journal-title":"Iran J Immunol"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15578"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3925\/jjtc.58.710"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:33:31Z","timestamp":1729470811000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.18009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,17]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/trf.18009"],"URL":"https:\/\/doi.org\/10.1111\/trf.18009","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,17]]},"assertion":[{"value":"2023-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}