{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:38:20Z","timestamp":1783841900502,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002494"],"award-info":[{"award-number":["UL1TR002494"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Low titer group O whole blood (LTOWB) is commonly used for severe bleeding in trauma patients. LTOWB may also benefit young children requiring cardiac surgery with cardiopulmonary bypass (CPB) at risk of severe bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>In this retrospective study, children &lt;2\u2009years old who underwent cardiac surgery with CPB were included. Comparisons were performed between those receiving component therapy (CT) versus those receiving LTOWB plus CT (LTOWB+CT). Outcomes included drainage tube (DT) output and total transfusion volumes. Optimization\u2010based weighting was used for adjusted analyses between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 117 patients transfused with only CT and 127 patients transfused with LTOWB+CT. In the LTOWB+CT group, 66 were Group non\u2010O and 61 were Group O. Total transfusion volumes given from the start of the operation until the first 24\u2009h in the cardiac intensive care unit was a median (IQR) 41 (10, 93) mL\/kg in the CT group and 48 (28, 77) mL\/kg in the LTOWB+CT group, (<jats:italic>p<\/jats:italic>\u2009=\u2009.28). Median (IQR) DT output was 22 (15\u201332) in CT versus 22 (16\u201328) in LTOWB+CT groups, (<jats:italic>p<\/jats:italic>\u2009=\u2009.27). There were no differences in death, renal failure and a composite of death and renal failure between the two groups, but there were statistically fewer re\u2010explorations for bleeding in the LTOWB+CT group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of LTOWB appears to be safe in &lt;2\u2009years old undergoing cardiac surgery and may reduce re\u2010explorations for severe bleeding. Large trials are needed to determine the efficacy and safety of LTOWB in this population with severe bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.18014","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T08:34:26Z","timestamp":1726216466000},"page":"2075-2085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Use of low titer <scp>O<\/scp> whole blood in infants and young children undergoing cardiac surgery with cardiopulmonary bypass"],"prefix":"10.1111","volume":"64","author":[{"given":"Massimo","family":"Griselli","sequence":"first","affiliation":[{"name":"Department of Cardio\u2010Thoracic Surgery, Cardiac Surgery King Abdullah bin Abdulaziz University Hospital and Princess Nourah Bint Abdulrahman University  Riyadh Saudi 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of Anesthesiology University of Minnesota, Masonic Children's Hospital  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Fahey\u2010Arndt","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine and Pathology Transfusion Medicine, Fairview Health Services  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Welbig","sequence":"additional","affiliation":[{"name":"M Health Fairview  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Beilman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Minnesota Translational Center for Resuscitative Trauma Care University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole D.","family":"Zantek","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n of Transfusion 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