{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T18:40:30Z","timestamp":1734028830970,"version":"3.30.2"},"reference-count":10,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Emergent transfusion is carried out without standard pre\u2010transfusion serologic testing to detect alloantibodies in patient plasma. Transfusion of red blood cells positive for antigens incompatible with a patient's current or historical alloantibodies risks acute and delayed hemolysis, which may be fatal. Symptomatic and prophylactic treatment of hemolysis secondary to transfusion of incompatible non\u2010ABO antigens using automated red cell exchange has been rarely reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>A 77\u2010year\u2010old female with extensive hemorrhage from a femoral artery pseudoaneurysm received a massive transfusion of uncrossmatched blood. Although subsequent testing of a pre\u2010transfusion sample was inconclusive, a search of a patient alloantibody registry showed a history of anti\u2010E, anti\u2010Fya, and anti\u2010Jk(a) antibodies, which were subsequently confirmed and proven incompatible with all 10 transfused red blood cell units in various combinations. Prior to the completion of repeat serologic testing, the historical alloantibody profile was used to allocate antigen\u2010negative units for automated red cell exchange to treat progressive transfusion\u2010related hemolysis. Treatment was completed without complications, and hemolysis gradually resolved without progression of hemodynamic instability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This case demonstrates successful automated red cell exchange following massive transfusion of red blood cells including a combination of three clinically significant incompatible antigens. Access to a patient alloantibody registry facilitates timely evaluation and management of transfusion\u2010associated adverse events which may otherwise be unavoidable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.18064","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T07:58:59Z","timestamp":1732003139000},"page":"2400-2404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>Massive<\/scp> transfusion of incompatible red blood cells: A case report demonstrating the benefits of a regional patient alloantibody registry and prompt automated red cell exchange"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7560-7155","authenticated-orcid":false,"given":"Keenan O.","family":"Hogan","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amitava","family":"Dasgupta","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Sosnovske","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2378-3813","authenticated-orcid":false,"given":"Zhan","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Kansas Medical Center  Kansas City Kansas USA"},{"name":"Community Blood Center of Kansas City  Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14370"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-08-833962"},{"issue":"2","key":"e_1_2_6_4_1","first-page":"390","article-title":"Hemolytic reaction caused by massive transfusion of incompatible blood, treated successfully by exchange transfusion","volume":"8","author":"Wiener AS","year":"1950","journal-title":"Exp Med Surg"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V110.11.4021.4021"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.14740\/jh541"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21461"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0154-CR"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17504"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13250"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15351"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.18064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T18:22:28Z","timestamp":1734027748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.18064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/trf.18064"],"URL":"https:\/\/doi.org\/10.1111\/trf.18064","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"type":"print","value":"0041-1132"},{"type":"electronic","value":"1537-2995"}],"subject":[],"published":{"date-parts":[[2024,11,18]]},"assertion":[{"value":"2024-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}