{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T05:05:22Z","timestamp":1739423122212,"version":"3.37.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T00:00:00Z","timestamp":1731801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201012\u20101\u20100441","EDMS 5570"],"award-info":[{"award-number":["W81XWH\u201012\u20101\u20100441","EDMS 5570"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01HL153072\u201001"],"award-info":[{"award-number":["1R01HL153072\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Volume\u2010reduced platelets can minimize circulatory overload, allergic transfusion reactions, or out\u2010of\u2010group plasma infusion. Our center adopted a volume reduction protocol that includes acidification with acid citrate dextrose solution A (ACD\u2010A) before centrifugation and without any rest period prior to resuspension allowing a better turnaround time for platelet issue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>This report compares corrected count increments (CCIs) from full\u2010volume and ACD\u2010A acidified volume\u2010reduced human platelets in a retrospective study at a single hospital and in a mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a pediatric tertiary care hospital, 530 patients received conventional apheresis platelets during the 20\u2010month study period. Among all patients, the expected 4\u2010h mean CCI was 9.8 (95% CI: 8.7, 10.9) for full\u2010volume platelets, and 8.8 (95% CI: 7.3, 10.6) for ACD\u2010acidified volume\u2010reduced platelets (<jats:italic>p<\/jats:italic>\u2009=\u2009.29). A statistically significant difference (<jats:italic>p<\/jats:italic>\u2009=\u2009.01) was identified in the expected 24\u2010h mean CCI: 6.3 (95% CI: 5.5\u20137.0) with full\u2010volume platelet, 4.7 (95% CI: 3.6\u20136.0) with ACD\u2010acidified volume\u2010reduced platelet. Limiting CCI calculations to patients with Hematology\/Oncology\/Hematopoietic Progenitor Cell Transplant diagnosis (<jats:italic>n<\/jats:italic>\u2009=\u2009296, 56%) indicated a statistically significant difference in both 4\u2010 and 24\u2010h predicted CCIs, showing lower CCIs in ACD\u2010acidified volume\u2010reduced platelet, although these were still similar to the CCIs observed in all patients and considered to be clinically acceptable responses similar to other volume reduction protocols. The recovery of count\u2010adjusted, volume\u2010reduced platelets was significantly lower in mice, suggesting a procedure\u2010related defect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>ACD\u2010A acidification of platelets before volume reduction decreases turnaround time for platelet issue and provides clinically allowable 4\u2010h and 24\u2010h platelet increments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.18067","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T06:59:00Z","timestamp":1731913140000},"page":"4-9","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utility of acid citrate dextrose\u2010acidification for platelet volume reduction protocols in the transfusion service"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9459-5296","authenticated-orcid":false,"given":"Yujung","family":"Jung","sequence":"first","affiliation":[{"name":"Bloodworks Northwest  Seattle Washington USA"},{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Virginia  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Nester","sequence":"additional","affiliation":[{"name":"Bloodworks Northwest  Seattle Washington USA"},{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chomkan","family":"Usaneerungrueng","sequence":"additional","affiliation":[{"name":"Bloodworks Northwest  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2866-1674","authenticated-orcid":false,"given":"Moritz","family":"Stolla","sequence":"additional","affiliation":[{"name":"Bloodworks Northwest  Seattle Washington USA"},{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"},{"name":"Department of Medicine, Division of Hematology and Oncology University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dwight","family":"Barry","sequence":"additional","affiliation":[{"name":"Clinical Analytics, Seattle Children's Hospital  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-1265","authenticated-orcid":false,"given":"Ann\u2010Marie","family":"Taroc","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Seattle Children's Hospital  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"},{"name":"Department of Laboratory Medicine and Pathology Seattle Children's Hospital  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-9201","authenticated-orcid":false,"given":"Nabiha H.","family":"Saifee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"},{"name":"Department of Laboratory Medicine and Pathology Seattle Children's Hospital  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,17]]},"reference":[{"volume-title":"AABB technical manual","year":"2023","author":"Claudia Cohn MD","key":"e_1_2_8_2_1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1984.24284173355.x"},{"key":"e_1_2_8_4_1","first-page":"23","article-title":"Effect of acidification in enhancing viability of platelet concentrates current status","volume":"17","author":"Aster RH","year":"1969","journal-title":"Vox Sang"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03357.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V51.5.781.781"},{"issue":"46","key":"e_1_2_8_7_1","first-page":"59","article-title":"The biomedical excellence for safer transfusion (BEST) collaborative","author":"AuBuchon JP","year":"2006","journal-title":"Platelet Radiolabeling Procedure. 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