{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T05:05:17Z","timestamp":1739423117652,"version":"3.37.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The provision of ABO\u2010incompatible fresh frozen plasma (FFP) in massive transfusion (MT) has become accepted to conserve AB FFP stock. There is an evidence gap in non\u2010trauma settings. We compare characteristics of patients who received ABO\u2010compatible or ABO\u2010incompatible FFP during an MT episode due to any cause of critical bleeding, and assess the impact of incompatible FFP transfusion on inhospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Australian and New Zealand Massive Transfusion Registry, data were extracted for patients aged \u226518\u2009years who received an MT (defined as \u22655 red cell units in 4\u2009h) between April 2011 and October 2018. Incompatible FFP was defined as transfusion of \u22651 unit of FFP with a bidirectional or minor ABO\u2010mismatch in the first 24\u2009h from MT initiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 7340 patients from 28 hospitals were included. Seventy\u2010seven (1%) patients received incompatible FFP (26 trauma, 51 non\u2010trauma). Those who had incompatible FFP received a median of seven units of FFP, compared to those who only received compatible FFP receiving five units, <jats:italic>p<\/jats:italic>\u2009=\u2009.005. A total of 226\u2009units of incompatible FFP were provided overall. Incompatible FFP provision was not independently associated with inhospital mortality in MT (HR of 1.40 [95% CI 0.84\u20132.26, <jats:italic>p<\/jats:italic>\u2009=\u2009.2]). Variables independently associated with inhospital mortality included increased FFP volume in the first 24\u2009h, age, Charlson Comorbidity Index score, and lower pre\u2010transfusion fibrinogen and peri\u2010transfusion pH values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transfusion of incompatible FFP in MT in our cohort was not independently associated with higher inhospital mortality, although the number of patients who received incompatible FFP was small.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.18070","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T08:34:56Z","timestamp":1735634096000},"page":"58-72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of massive transfusion recipients administered <scp>ABO<\/scp>\u2010incompatible fresh frozen plasma"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9253-6635","authenticated-orcid":false,"given":"Joanna Bao\u2010Ern","family":"Loh","sequence":"first","affiliation":[{"name":"Transfusion Research Unit, School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Haematology Monash Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron","family":"Wellard","sequence":"additional","affiliation":[{"name":"Transfusion Research Unit, School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen E.","family":"Haysom","sequence":"additional","affiliation":[{"name":"Transfusion Research Unit, School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6689-2983","authenticated-orcid":false,"given":"Rosemary L.","family":"Sparrow","sequence":"additional","affiliation":[{"name":"Transfusion Research Unit, School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica M.","family":"Wood","sequence":"additional","affiliation":[{"name":"Transfusion Research Unit, School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Haematology Monash Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9698-7185","authenticated-orcid":false,"given":"Zoe K.","family":"McQuilten","sequence":"additional","affiliation":[{"name":"Transfusion Research Unit, School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Haematology Monash Health  Melbourne Victoria Australia"},{"name":"Department of Haematology Alfred Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3180324124"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.12"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.51429"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/tmrv.2003.50003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2022.100989"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12537"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12730"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ta.0000000000001532"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31828b813e"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14139"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16008"},{"volume-title":"Guidelines for transfusion and immunohaematology laboratory practice","year":"2016","author":"Transfusion Science Standing Committee","key":"e_1_2_9_13_1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14804"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2019.09.036"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-016-2261-6"},{"key":"e_1_2_9_17_1","unstructured":"Lifeblood ARC. 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